高血压病患者血浆同型半胱氨酸水平与动脉硬化的相关性分析  

Correlation analysis between homocysteine level and arteriosclerosis in high blood pressure patients in routine medical examination

作　　者：周磊[1] 范茂丹[1] 杨敏[1] 孙国栋[1] 

机构地区：[1]南京军区杭州疗养院海勤疗养区,杭州310002

出　　处：《海军医学杂志》2016年第5期411-414,共4页Journal of Navy Medicine

摘　　要：目的探讨高血压病患者血浆同型半胱氨酸(homocysteine,Hcy)水平与动脉硬化的相关性。方法入选420例高血压病患者及192例健康体检人员作为研究对象,健康体检人员作为对照组,高血压病患者根据血浆Hcy水平分为Hcy正常组、Hcy轻度升高组、Hcy显著升高组。应用自动脉搏波速度测定仪测定颈动脉-股动脉脉搏波速度(CFPw V)作为评估动脉硬化的参数。比较4组血压参数、Hcy水平及CFPw V水平,计算各组动脉硬化发生率;将高血压病患者的各因素与CFPw V进行Pearson相关分析及多元线性回归分析。结果 (1)与对照组比较,血压各参数、Hcy及CFPw V在Hcy正常组、Hcy轻度升高组、Hcy显著升高组中均明显升高(P<0.05)。与Hcy正常组比较,血压各参数、Hcy及CFPw V在Hcy轻度升高组、Hcy显著升高组中明显升高(P<0.05)。与Hcy轻度升高组比较,Hcy显著升高组收缩压(SBP)、Hcy、CFPw V明显增高(P<0.05);(2)动脉硬化的发生率在Hcy轻度升高组、Hcy显著升高组中高于Hcy正常组(P<0.05);(3)Pearson相关分析显示,高血压患者的CFPwV与年龄、SBP、舒张压(DBP)、脉压(PP)、平均动脉压(MAP)、Hcy呈正相关(P<0.01);多元线性回归分析结果显示Hcy、SBP、PP是CFPw V的独立影响因素。结论 Hcy、SBP、PP是CFPw V的独立影响因素,高Hcy水平与高血压具有协同作用,放大了高血压导致动脉硬化的风险,并共同参与动脉硬化的发生发展。Objective To study the correlation between homocysteine （Hey） level and arteriosclerosis in hypertension patients. Methods Four hundred and twenty hypertension patients （assigned as the experimental group） and 192 healthy examinees （assigned as the control group） were recruited for the study, and the hypertension patients were further subdivided into the normal Hey group, the slightly higher Hey group and the obviously high Hey group, in accordance with the plasma levels of Hey. Carotid-femoral pulse wave velocity （CFPwV） was measured by automatic pulse wave velocity detector and was used as an arteriosclerosis indicator. Blood pressure parameters, Hey levels, CFPwV levels were compared between the 4 groups and the incidence of atherosclerosis for each group were calculated accordingly. Then, Pearson correlation analysis and multiple regression analysis were performed in all the associated factors of hypertension with CFPwV. Results （ 1） As compared with those of the control group, the levels of systolic blood pressure （SBP） , diastolic blood pressure （DBP） , mean arterial blood pressure （MAP） , pulse pressure （PP） , Hey and CFPwV increased in all the experimental groups （ P 〈 0. 05 ） . As compared with those of the Hey normal group, the levels of SBP, DBP, MAP, PP, Hey and CFPwV increased in the slightly higher Hey group and the obviously high Hey group （P 〈0. 05）. And as compared with those of the slightly higher Hey group, the levels of SBP, Hey and CFPwV in the obviously high Hey group all elevated significantly （ P 〈0. 05）. （2） The incidence of atherosclerosis in the slightly higher Hey group and the obviously high Hey group was higher than those of the normal Hey group （P 〈 0. 05 ）. （ 3 ） Pearson correlation analysis revealed that CFPwV was positively correlated with age, SBP, DBP, PP, MAP and Hey. Results of multiple linear regression analysis indicated that Hey, SB

关 键 词：高血压病 同型半胱氨酸 动脉硬化 脉搏波传导速度 

分 类 号：R543.12[医药卫生—心血管疾病] R544.1[医药卫生—内科学]