沙漠干热环境不同温度对创伤失血性休克猪生存时间的影响  

The Effect of Survival on Traumatic Hemorrhagic Shock Pigs in Different Temperature of Desert Dry-heat Environment

作　　者：沈才福 刘江伟[2] 钱若筠[2] 安宗仁 段越[1] 是文辉[2] 董翔[2] 许永华[2] 

机构地区：[1]石河子大学医学院,石河子832000 [2]新疆军区总医院新疆特殊环境医学重点实验室,乌鲁木齐830000

出　　处：《实验动物科学》2016年第4期48-51,共4页Laboratory Animal Science

基　　金：总后勤部面上基金项目(No.CLZ13J004)

摘　　要：目的探讨沙漠干热环境下不同温度对创伤失血性休克猪生存时间的影响,为进一步的研究提供理论依据。方法选取雄性的长白仔猪30头(25—35 kg),随机分为常温实验组(环境温度25℃±1℃,湿度35%±5%,n=10),干热环境Ⅰ组(环境温度40.5℃±0.5℃,湿度10%±2%,n=10头),干热环境Ⅱ组(环境温度41.5℃±0.5℃,湿度10%±2%,n=10头)。将实验动物置于人工实验舱内,按实验设计设置相应的环境参数,分别在各自环境暴露3 h,建创伤失血性休克模型,观察生命体征及死亡时间。结果 1.常温组创伤失血性休克后体温较长时间稳定在一定水平,稳定期后呈进行性下降;而干热Ⅰ组休克后缓慢上升,两相邻时间点温度无显著差异;干热Ⅱ组模型成功后体温很快升至42℃,一直呈快速上升趋势,直至动物死亡,相邻两时间点体温差异显著。2.常温组模型成功后三组的平均存活时间分别是(567±16.9)min、(178±3.6)min、(61±2.8)min,三组平均生存时间差异显著。结论 1.沙漠干热环境创伤失血性休克存活时间明显短于常温环境,提示沙漠干热环境可加速创伤失血性休克动物死亡;2.而沙漠干热环境Ⅱ组存活时间更短,提示在沙漠干热环境下,环境每升高1℃,可明显缩短创伤失血性休克猪的生存时间。3.体温升高的速度与死亡速度呈正相关,温度升高越快死亡时间快,生存时间越短,提示沙漠干热环境创伤失血性休克救治过程中有效地控制体温可能具有重要的临床意义。Objective Trauma hemorrhagic shock swines were explored the effect of survival in different temperature of desert dry-heat environment,to provide a theoretical basis for the further research. Method Local male Landrace piglets（25 -35 kg） were randomly divided into three group： normal temperature group （temperature： 25℃±1℃ ,humidity 35% ±5%, n = 10）; dry-heat group I （ temperature 40.5℃±0.5℃, humidity 10% ± 2% , n = 10） ; dry-heat group]] （ temperature 41.5℃±0.5℃, humidity 10%±2% , n = 10）. They were placed in a ~cabin （The Simulated Climate Cabin for Special Environment of Northwest of China, Urumqi of China）. Parameters of environmental are set according to experimental design, exposuring three hours in their environment, respectively. They were established to model the signs and the time of death. Result 1. In the traumatic hemorrhagic shock, and to observe the normal temperature group, the body temperature changes of vital was stable at a certain level after traumatic hemorrhagic shock, and the trend was decreased after the stabilization period; the dry- heat group I after the shock rise slowly, and there was no significant difference between the two adjacent time point temperature; dry-heat group II after the shock temperature quickly rose to 42℃, has shown a rapid upward trend until death, and the adjacent time point temperature difference is significant. 2. The average survival time of the three group after shock were （567 ± 16.9） min, （ 178 ± 3.6） min, （61 ±2. 8） min, respectively. The survival time of the three groups was significantly different. Conclusion 1. Dry-heat environment traumatic hemorrhagic shock survival time was significantly shorter than room temperature environment, suggesting that dry-heat environment can be accelerated the death of animal in traumatic hemorrhagic shock. 2. The dry-heat group II survival time shorter, suggesting that the environment increases every 1 degrees in this environment, can significantly shorten the traum

关 键 词：干热环境 创伤失血性休克 温度 体温 生存率 

分 类 号：Q494[生物学—生理学]