糖化血红蛋白与尿微量白蛋白联合检测诊断早期2型糖尿病肾病的价值  

Diagnostic value of HbA1 c combined with u -ALB in early type 2 diabetes

作　　者：郑华荣[1] 胡建军[1] 姚燕[1] 陆英[1] Zheng Huarong Hu Jianjun Yao Yan Lu Ying(Department of Laboratory, Changshan Peoples Hospital,Zhejiang 324200, Chin)

机构地区：[1]浙江省常山县人民医院检验科,324200

出　　处：《中国基层医药》2016年第20期3159-3162,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：探讨糖化血红蛋白（HbA1c）和尿微量白蛋白（u-ALB）含量检测在2型糖尿病肾病早期诊断中的价值。方法选择200例2型糖尿病患者作为糖尿病组，另外选择健康人群30例作为对照组。根据 HbA1c 含量将糖尿病组患者分为低值组（HbA1c ＜7％）、中值组（7．1％≤HbA1c≤10％）和高值组（HbA1c ＞10．1％）。测定各组 HbA1c、u-ALB 含量，并计算两者之间的相关性。结果糖尿病组 HbA1c （8．85±1．22）％、u-ALB（88．3±12．4）mg／L，均显著高于对照组（t ＝10．88、54．25，均 P ＜0．05）；糖尿病高、中、低值组HbA1c[（11．02±1．37）％、（8．45±2．01）％、（6．88±1．23）％]均与各自空腹血糖水平[（13．22±2．05）mmol／L、（9．25±1．28）mmol／L、（6．27±0．63）mmol／L]变化一致；糖尿病各组 HbA1c 与 u-ALB 水平呈正相关（r ＝0．452、0．512、0．968，均 P ＜0．05）。结论联合检测 HbA1c 和 u-ALB 水平对于诊断早期2型糖尿病肾病具有重要价值。Objective To investigate the value of glycated hemoglobin（HbA1c）and urine trace albumin （u -ALB）content in early diagnosis of type 2 diabetic nephropathy.Methods 200 patients with type 2 diabetes were selected as diabetes group,and 30 cases of healthy people as control group.According to the content of HbA1c, the diabetes patients were re -divided into low group （HbA1c 〈7%）,the median group（7.1%≤HbA1c≤10%） and high value group （HbA1c 〉10.1%）.The levels of HbA1c and u -ALB were detected and the correlation between them was calculated.Results The values of HbA1c （8.85 ±1.22）% and u -ALB （88.3 ±12.4）mg/L in the diabetes group were significantly higher than those of the control group （t =10.88,54.25,all P 〈0.05）;The level of HbA1c in the high,medium and low group[（11.02 ±1.37）%,（8.45 ±2.01）%,（6.88 ±1.23）%]were consistent with the levels of the respective levels of fasting glucose[（13.22 ±2.05）mmol/L,（9.25 ±1.28）mmol/L, （6.27 ±0.63）mmol/L].HbA1c and constituting the u -ALB levels were positively correlated in the high,medium and low group（r =0.452,0.512,0.452,all P 〈0.05）.Conclusion The combined detection of HbA1c and u -ALB levels has important value for early diagnosis of type 2 diabetic nephropathy.

关 键 词：糖尿病肾病 糖尿病 2 型 糖化血红蛋白 尿微量白蛋白 

分 类 号：R587.2[医药卫生—内分泌]