茵栀黄颗粒联合双歧杆菌四联活菌片对早产儿肠道菌群及胆红素水平的影响  

Effect of Yinzhihuang Particle Combined with Bifidobacterium Quadruple Viable Chip on Intestinal Flora and Bilirubin of Premature Infant

作　　者：刘艳辉[1] 刘丽娟[1] 

机构地区：[1]廊坊市广阳区妇幼保健院,河北廊坊065000

出　　处：《中医学报》2016年第9期1401-1404,共4页Acta Chinese Medicine

基　　金：河北省科技攻关项目(20150039)

摘　　要：目的:观察茵栀黄颗粒联合双歧杆菌四联活菌片对早产儿肠道菌群及胆红素水平的影响,并观察两组患儿的临床疗效。方法:将198例早产儿按随机数字表法分为治疗组100例,对照组98例。对照组采用口服茵栀黄颗粒常规治疗,每次6 g,每日3次;治疗组在对照组治疗基础上加服双歧杆菌四联活菌片治疗,每次1片,每日2次。观察两组患儿的临床疗效、肠道菌群及胆红素水平。结果:治疗组经治疗28 d后,患儿体质量增长速度明显优于对照组,且喂养不耐受的发生率明显低于对照组,差异有统计学意义(P<0.05)。两组患者血清胆红素浓度比较,治疗组显著低于对照组,未发现益生菌相关败血症的发生,差异有统计学意义(P<0.05)。结论:双茵栀黄颗粒联合双歧杆菌四联活菌片能明显改善早产儿胃肠道功能,对早产儿喂养及生长发育有较好作用,减少喂养不耐受的发生率,抑制血清胆红素水平,对预防高胆红素血症也有重要意义。Objective ： To observe the effect of Yinzhihuang particle Combined with Bifidobacterium quadruple viable chip on intesti- nal flora and hilirubin of premature infant and the clinical efficacy. Methods ： 198 cases of preterm infants were randomly divided into treatment group （100 cases） and control group （98 cases）. The control group was treated with Yinzhihuang Particles and the treatment group was treated with Bifidobacterium quadruple viable chip in addition of that of the control group. The clinical effica- cies, the intestinal flora and the bilirubin levels of both groups were observed after treatment. Results：After 28 d＇s treatment, the infants＇ body mass growth rate of the treatment group was significantly higher than that of the control group （P 〈 0.05 ） ,and the incidence of feeding intolerance of the treatment group was significantly lower than that of the control group （P 〈 0. 05）. The ser- um bilirubin level of the treatment group was significantly lower than that of the control group, with the difference being statistically significant （P 〈 0.05 ） and there was no case of probiotics-related sepsis. Conclusion ： Yinzhihuang particle combined with Bifidobacterium quadruple viable chip can effectively improve the gastrointestinal function of premature infant and better help with the feeding of them by reducing the incidence of feeding intolerance rate and inhibiting the serum bilirubin level, which is of great significance in prevention of hyperbilirubinemia.

关 键 词：茵栀黄颗粒 双歧杆菌四联活菌片 早产儿 肠道菌群 胆红素 中医药疗法 中西医结合 

分 类 号：R272.1[医药卫生—中医儿科学]