血竭提取物抗大鼠实验性心律失常作用研究  

Antiarrhythmic Effect of Dragon's Blood Extract on Experimental Arrhythmias in Rats

作　　者：韦润峰 龚园球 李达汉[1] 林洁[1] 韦秋社 王若琦[1,2] 

机构地区：[1]右江民族医学院,广西百色533000 [2]右江民族医学院附属医院心脏内科,广西百色533000

出　　处：《亚太传统医药》2016年第21期13-14,共2页Asia-Pacific Traditional Medicine

基　　金：广西高校大学生创新计划项目(201510599067);广西高校大学生创新计划项目(201510599003);广西中医药管理局中医药科技专项课题(GZKZ09-87);广西中医药管理局自筹科研课题(g22c1046)

摘　　要：目的:明确血竭提取物对大鼠实验性心律失常的作用并且探讨可能的机制。方法:研究采用随机对照动物实验设计,以血竭提取物为研究用药,大鼠随机分为模型组、血竭提取物低剂量组、血竭提取物中剂量组和血竭提取物高剂量组。分别对氯化钡和肾上腺素诱发的大鼠心律失常模型进行研究,观察给药后心律失常出现时间、持续时间及心律失常发生数。结果:与模型组比较,血竭提取物能够显著降低模型的静息心率,延长氯化钡和肾上腺素诱发的室性心律失常和其他心律失常的出现时间并能够缩短心律失常持续时间。结论:血竭提取物可有效对抗氯化钡和肾上腺素诱发的实验性大鼠心律失常。Objective： To discuss the effect and mechanism of dragon＇s blood extract in antagonizing arrhythmia in rats. Methods： SD rats were randomly dicided into four groups：model group,low-dose group, mid-dose group and high-dose group. The rat model of arrhythmia was induced by barium chloride and adrenaline epinephrine. The relative indexes of electrocardiogram （ECG） were ob- served and analyzed. Results：Compared with model group, dragon＇s blood extract can lower resting heart rate, prolong the latent time of ventricular arrhythmia, delay the onset time and shortened duration of arrhythmia induced by induced by barium chloride and adrenaline epinephrine. Conehlsion： Dragon＇s blood extract have the effects on antiarrhythmia, can effectively antagonize the experi- ment alarrhythmia induced by barium chloride and adrenaline epinephrine in rats.

关 键 词：血竭提取物 实验性心律失常 抗心律失常 

分 类 号：R255.2[医药卫生—中医内科学]