雷公藤中毒原因及减毒方法文献分析  

Analysis of Literature about Tripterygium Wilfordii Poisoning Reasons Aand Detoxicifying Methods

作　　者：黄妮[1] 刘钟颖 张珍花[1] 黄先菊[1] 程寒[1] 

机构地区：[1]中南民族大学药学院,湖北武汉430074

出　　处：《亚太传统医药》2016年第21期48-51,共4页Asia-Pacific Traditional Medicine

基　　金：湖北省自然科学基金创新群体项目(2013CFA013);湖北省教育厅教学研究项目(2012197);中南民族大学中央高校基本科研业务费专项资金资助项目(CZZ16004)

摘　　要：目的:了解雷公藤的毒性作用机制以及对雷公藤化学成分的减毒方法。方法:通过统计近十年中文数据库中633例雷公藤药物中毒的资料,探讨和分析病例来源、化学成分来源、中毒原因、临床表现、中毒预后情况、毒性作用机制以及减毒措施等方面。结果:雷公藤的毒副作用发生率为58.1%,雷公藤含有多种化学成分,这些成分使其具有广泛的临床药效,但也可能是造成其毒性大的原因。结论:提出雷公藤的中毒原因以及一些减毒措施,有助于控制雷公藤的毒性,为其在临床上的应用提供参考,减少中毒事件的发生。Objective. To have a better understanding of tripterygium wilfordii toxicity mechanism as well as handling the detoxif- ying. Methods： Statistics of 633 cases of tripterygium wilfordii poisoning in the Chinese database in the past decade, discussing and analyzing the source of cases and chemical components, the cause of poisoning, the clinical manifestation, the poisoning prognosis, thetoxicity mechanism and the detoxifying methods etc. Results. The rate of side effects happening is 58. 1%, since there are hundreds of chemical components contained in tripterygium wilfordii, no wonder that it has such a wide range of clinical behaviors and strong toxins. Conclusion. Through the documentary research and analysis, the question for tripterygium wilfordii poisoning and some detoxifying methods was raised, it is benificial for tripterygium wilfordii toxin control and provide certain references for its clinical application, and also help reducing the occurrence of the poisoning.

关 键 词：雷公藤 中毒 减毒 合理运用 

分 类 号：R282.71[医药卫生—中药学]