3-芳基-2-硝基丙醇的合成新方法  

A new Method for Synthesis of 3-aryl-2-nitropropanol

作　　者：梁弘[1,2] 李齐激[2] 杨艳[2] 潘雄[2] 杨娟[2] 杨小生 

机构地区：[1]贵州大学药学院,贵州贵阳550002 [2]贵州省中国科学院天然产物化学重点实验室,贵州贵阳550002

出　　处：《山地农业生物学报》2016年第3期44-48,共5页Journal of Mountain Agriculture and Biology

基　　金：贵州省高层次创新型人才培养(百层次)(黔科合人才[2015]4027号)

摘　　要：研究β-硝基醇类化合物3-芳基-2-硝基丙醇的合成新方法。在碱催化作用下,2-芳基硝基乙烷和甲醛进行缩合,筛选、优化2-芳基硝基乙烷与甲醛反应所需碱的类型和温度,合成3-芳基-2-硝基丙醇。以醋酸钠作为碱,反应温度为30℃时,2-芳基硝基乙烷与过量甲醛能高收率地反应生成3-芳基-2-硝基丙醇。该合成方法有效和反应条件易控,可用于3-芳基-2-硝基丙醇的批量制备。Here we reported a new synthetic method for 3-aryl-2-nitropropanols. Different bases and temperature condi-tion were screened and optimized for the condensation reaction of 2-aryl nitroethane with formaldehyde in methanol. （±） 3-aryl-2-nitropropanols were obtained in high yields by reaction conditions with sodium acetate as base and temperature at 30℃ . The synthetic method was effective and available for a large amount of production of 3-aryl-2-nitropropanol.

关 键 词：3-芳基-2-硝基丙醇 甲醛 醋酸钠 

分 类 号：Q621.3[生物学—生物物理学]