男性不育症患者精子形态与精子密度、活力相关性及影响因素研究  

Relationship between sperm morphology and sperm concentration,vitality and its influencing factors in infertile men

作　　者：仲纪祥[1] 张连美[2] 冯播[1] 左阳花[1] Zhong Jixiang et al(Infertility Department, Huai＇an Maternal and Child Health Hospital, Huai＇an 223400, Chin)

机构地区：[1]淮安市妇幼保健院不孕不育科,江苏223400 [2]淮安市第一人民医院病理科

出　　处：《齐齐哈尔医学院学报》2016年第22期2778-2780,共3页Journal of Qiqihar Medical University

摘　　要：目的探讨男性不育症患者精子形态与精子密度、活力相关性及影响因素。方法选取2013年7月至2015年7月期间于本院不孕不育科就诊的500例男性不育症患者作为研究对象,根据患者的精子密度、活力和畸形率分组,比较不同组患者的精子畸形率和TZI,分析精子形态正常组和异常组患者的相关资料,采用Logistic多因素回归分析男性不育症患者精子畸形率影响因素。结果精子密度〉50（×10^6/ml）组患者精子形态正常率显著高于精子密度15～50（×10^6/ml）组和精子密度〈15（×10^6/ml）组患者（P〈0.05）,精子密度〉50（×10^6/ml）组患者精子TZI显著低于精子密度15～50（×10^6/ml）组和精子密度〈15（×10^6/ml）组患者（P〈0.05）;精子活力〉60%组患者精子形态正常率显著高于32%～60%组和〈32%组患者（P〈0.05）,精子活力〉60%组患者TZI显著低于精子活力〈32%组患者（P〈0.05）;精子形态正常组患者年龄、吸烟及酗酒比例显著低于精子形态异常组患者,精子形态正常组患者精子密度及活力显著高于精子形态异常组患者（P〈0.05）;Logistic多因素回归分析结果显示精子密度、精子活力、吸烟及酗酒是精子形态的影响因素。结论精子密度及活力异常的男性不育症患者常伴有畸精症,不良生活习惯影响精子形态,值得临床加以关注。Objective To explore the male infertility patients with sperm morphology and sperm concentration,vitality and impact of relevant factors. Methods During July 2013 to July 2015 in our Hospital Reproductive Center,500 cases of male infertility patients were selected to study,according to the sperm concentration of patients,vitality and deformity rate,the patients were divide into some groups,to compare sperm deformity rate and TZI of different groups,to analyze the data of normal sperm morphology group and abnormal group and influencing factors of male infertility patients with sperm deformity rate by logistic regression analysis.Results Sperm morphology normal rate of sperm density 50（ ×10^6/ ml） group patients was significantly higher than that of sperm density 15 ～ 50（ ×10^6/ ml） group and sperm density 15（ patients in × 10^6/ ml） group（ P〈0.05）,sperm TZI of sperm density 50（ ×10^6/ ml） patients was significantly lower than that of the sperm density15 ～ 50（ ＊ 10^6/ ml） group and sperm density 15（ ×10^6/ ml） group（ P〈0.05）; sperm morphology normal rate of sperm motility 60% patients was significantly higher than that of 32% ～ 60% group and 32% group（ P〈0.05）,TZI of sperm Activity 60% patients was significantly lower than that of sperm motility 32% patients（ P〈0.05）; the age,smoking and alcoholism rates of sperm with normal morphology group were significantly lower than that of abnormal sperm morphology group,the sperm density and activity of sperm morphology in normal group was significantly higher than that of sperm morphology abnormal group patients（ P〈0. 05）; logistic regression analysis showed that sperm density,sperm motility,smoking and drinking were the influencing factors of sperm morphology. Conclusions Sperm density and motility abnormalities in patients with male infertility is often accompanied by abnormal azoospermia and bad habits which affect sperm morphology,which deserves clinical attention.

关 键 词：男性不育症 精子形态 精子密度 精子活力 

分 类 号：R339.2[医药卫生—人体生理学]