Utilization of bromine azide to access vicinal-azidobromides from arylidene malononitrile  被引量:1

Utilization of bromine azide to access vicinal-azidobromides from arylidene malononitrile

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作  者:Hanan A.Soliman Tamer K.Khatab Farouk M.E.Abdel-Megeid 

机构地区:[1]Photochemistry Department, National Research Centre [2]Organometallic and Organometalloid Chemistry Department, National Research Centre

出  处:《Chinese Chemical Letters》2016年第9期1515-1518,共4页中国化学快报(英文版)

摘  要:An efficient and facile approach for tetrachlorosilane as an in situ mediated transformation via a one-pot, synthesis of vicinal bromoazides through the generation of BrN3 from azidochlorosilane and N-bromosuccinimide in acetonitrile as solvent at ambient temperature is achieved. This catalytic process represents a highly regioselective and high yielding method for the synthesis of 1,2- bromoazides. Thiamine pyrophosphate (TPP) riboswitches regulate essential genes in bacteria by changing conformation upon binding intracellular TPP. Molecular docking studies are conducted to understand the orientation and the interaction of each synthesized molecules with TPP riboswitches, 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academv of Medical Sciences.An efficient and facile approach for tetrachlorosilane as an in situ mediated transformation via a one-pot, synthesis of vicinal bromoazides through the generation of BrN3 from azidochlorosilane and N-bromosuccinimide in acetonitrile as solvent at ambient temperature is achieved. This catalytic process represents a highly regioselective and high yielding method for the synthesis of 1,2- bromoazides. Thiamine pyrophosphate (TPP) riboswitches regulate essential genes in bacteria by changing conformation upon binding intracellular TPP. Molecular docking studies are conducted to understand the orientation and the interaction of each synthesized molecules with TPP riboswitches, 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academv of Medical Sciences.

关 键 词:Azidobromination Tetrachlorosilane Arylidene malononitrile Sodium azide N-Bromosuccinimide 

分 类 号:O621.3[理学—有机化学]

 

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