One-pot synthesis of [1+1] and 62-membered [2+2] Schiff base macrocycles  

作　　者：Fang-Fang Wang Ya-Xin Deng Chao Huang Qi-Long Zhang Bi-Xue Zhu 

机构地区：[1]Key Laboratory of Macrocyclic and Supramolecular Chemistry, Guizhou University [2]Department of Chemistry, Guizhou Medical College

出　　处：《Chinese Chemical Letters》2016年第9期1551-1553,共3页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China (No. 21061003);the ‘Chun-Hui’ Fund of Chinese Ministry of Education (No. Z2012054)

摘　　要：New [1＋1] and 62-membered [2＋2] Schiff base macrocycles containing a 2,6-diamidopyridine subunit have been synthesized by condensation reaction of the precursors pyridine-2,6-dicarboxamide and 1,10- bis（2＇-formylphenyloxy）decane in the presence of phosphoric acid via a one-pot process. The cyclo- condensed products were effectively isolated by gel column chromatography and characterized by 1H NMR, FTIR, mass spectrometry and X-ray analysis. The two macrocycles have a twisted structure, and not an open ＇circular＇ conformation in the solid state.New [1＋1] and 62-membered [2＋2] Schiff base macrocycles containing a 2,6-diamidopyridine subunit have been synthesized by condensation reaction of the precursors pyridine-2,6-dicarboxamide and 1,10- bis（2＇-formylphenyloxy）decane in the presence of phosphoric acid via a one-pot process. The cyclo- condensed products were effectively isolated by gel column chromatography and characterized by 1H NMR, FTIR, mass spectrometry and X-ray analysis. The two macrocycles have a twisted structure, and not an open ＇circular＇ conformation in the solid state.

关 键 词：Macrocycles Schiff base One-pot synthesis Crystal structure 

分 类 号：O621.3[理学—有机化学]