急性肺损伤中过氧化物酶体增殖物激活受体γ通路参与保护作用的阶段性研究  

Staged research of peroxisome proliferator-activated receptor γ pathway involved in protection against acute lung injury

作　　者：冯迪[1] 朱梦怡 吕欣[1] 

机构地区：[1]同济大学附属肺科医院麻醉科,上海200433

出　　处：《国际麻醉学与复苏杂志》2016年第10期945-947,960,共4页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金（81272142）;上海市卫生和计划生育委员会中医药科研基金（2014LP037A）

摘　　要：背景急性肺损伤（acute lung injury，ALl）在临床上主要表现为严重的低氧血症、弥漫性肺浸润和肺微血管通透性增高所致的肺水肿。目前认为，ALI的主要发病机制为炎症反应失衡，促炎因子大量释放。过氧化物酶体增殖物激活受体γ（peroxisome proliferator-activated receptor1，PPARl）是调节目的基因表达的核内受体转录因子超家族成员，主要表达于脂肪组织以及巨噬细胞和其他脂肪贮存细胞。目的介绍PPARγ在ALI中的保护作用。内容PPARγ具有广泛的抗炎作用，近年来的研究发现其在ALI的保护方面具有重要作用。趋向为预防和治疗ALI提供新思路。Background Acute lung injury （ALl） is characterized by severe hypoxemia, diffuse pulmonary infiltration and increased pulmonary microvaseutar permeability accompanied by pulmonary edema. It is now believed that the main pathogenesis underlying ALl is the imbalance of inflammation reaction and release of abundant proinflammatory factors. Peroxisome proliferator activated receptor γ （PPARγ） is the superfamily member of nuclear receptor transcription factor and is belong to a subfamily of the nuclear receptor superfamily, which regulate the expression of its target genes and are mainly expressed on adipose tissue. macrophages as well as other fat- storing cells. Objective To describe the PPARγ pathway involved in protecuon agamst ALl. Content PPARγ possesses extensive anti-inflammatory action. Furthermore, recent researches have shown that PPARγ plays an important role in protection against ALl. Trend New ideas for prevention and treatment of ALl are provided.

关 键 词：过氧化物酶体增殖物激活受体Γ 急性肺损伤 炎症 

分 类 号：R563.8[医药卫生—呼吸系统]