离体狗喉模型中声门闭合不全程度对发声的影响  

Effect of extent of glottal incompetence on phonation in excised canine larynx models

作　　者：侯光辉[1] 王睿卿[1] 杨帅[2] 张宇[2] 徐新林[3] 庄佩耘[3] 

机构地区：[1]厦门大学医学院临床医学系,361005 [2]厦门大学海洋与地球学院应用海洋物理与工程系,361005 [3]厦门大学附属中山医院耳鼻咽喉科,361004

出　　处：《中华耳鼻咽喉头颈外科杂志》2016年第10期768-772,共5页Chinese Journal of Otorhinolaryngology Head and Neck Surgery

基　　金：基金项目：国家自然科学基金（NSFC81371080）;福建省卫生系统中青年骨干人才培养项目（2013-ZQN-JC-35）

摘　　要：目的 探讨声门下压（sub-glottal pressure,SGP）变化、声门闭合不全（glottal incompetence,GI）程度变化与声信号、黏膜波、空气动力学参数[发声起始阈压（phonation threshold pressure,PTP）]变化之间的关系.方法 采用11只离体狗喉分别制作正常模型（对照组,n=11）和1 mm、2 mm、3 mm的GI模型（实验组,每组n均为11）,随后进行发声实验,收集声信号,观察黏膜波,同时测量PTP.采用扰动方法、边沿提取及曲线拟合算法分析,比较声信号参数[频率微扰值（jitter）、振幅微扰值（shimmer）]、黏膜波参数[频率（frequency,F）、振幅（amplitude,A）、相位差（phase,P）]、空气动力学参数（PTP）对GI程度及SGP变化（1～4 kPa）的敏感性.以SPSS 17.0软件对数据进行统计学分析 结果 不同SGP和GI程度组间jitter、shimmer的差异均具有统计学意义（P值均＜0.05）.在对照组及GI 1 mm组中,当SGP上升到3 kPa时,jitter、shimmer出现明显变化;在GI 2 mm及3 mm组中,SGP上升到2 kPa时,jitter、shimmer出现明显变化.声带黏膜波的F、A随SGP增加而增加,随GI程度的增大而减小,组间差异均具有统计学意义（P值均＜0.05）,P在不同SGP和GI程度的组间差异没有统计学意义（P值均＞0.05）.PTP在不同GI程度组间的差异具有统计学意义（P＜0.05）.结论 SGP和GI程度对声信号、黏膜波及PTP有显著影响.Objective To compare the acoustic signal,mucosal wave and aerodynamic parameter （phonation threshold pressure,PTP） under different sub-glottal pressure （SGP） on the excised canine models with different extent of glottal incompetence.Methods Perturbation measures and nonlinear dynamic measures were applied to analyze the acoustic signal （jitter,shimmer）,mucosal wave [frequency （F）,amplitude （A）,phase （P）] and PTP from our study including 11 excised canine larynges with different extent of glottal incompetence （0 mm,1 mm,2 mm,3 mm,n =11,respectively） under 1-4 kPa sub-glottal pressure.Results There were significant differences between different groups in jitter,shimmer,amplitude,frequency and PTP under various SGPs and extent of glottal incompetence （all P 〈 0.05）,inversely,there was no significant difference in P between groups （P 〉 0.05）.Jitter and shimmer changed obviously when the SGP increased to 3 kPa in the control group and GI 1 mm group.Jitter and shimmer changed obviously when the SGP increased to 2 kPa in the GI 2 mm and 3 mm groups.The F and A of mucosal wave increased with increasing SGP,decreased with increasing GI,and the P changed irregularly.There was statistically significant difference of PTP between different GI groups.Conclusions The SGP and the extent of GI had obvious affection on the the acoustic signal,mucosal wave and aerodynamic parameters.

关 键 词：声刺激 声门 发声 

分 类 号：R767.92[医药卫生—耳鼻咽喉科] R-332[医药卫生—临床医学]