口服阿司匹林预防大肠腺瘤复发的临床研究  

Efficacy of oral high-dose aspirin on preventing recurrence of colorectal adenoma

作　　者：宋自昌 周瑶军[1] 王矩伟[1] 

机构地区：[1]濮阳市油田总医院重症医学科,河南濮阳457001

出　　处：《医药论坛杂志》2016年第10期58-59,共2页Journal of Medical Forum

摘　　要：目的通过搜集大肠腺瘤的患者口服大剂量阿司匹林预防大肠腺瘤复发的有效性。方法临床上行肠镜检查的发现息肉并行内镜切除病理检查为大肠腺瘤的患者150例,随机分为观察组75人和对照组75人,观察组口服阿司匹林200mg/d,对照组口服安慰剂,随访半年后行肠镜检查。结果观察组共有67例完成随访,其中共有12例复发大肠腺瘤,对照组共有73例完成随访,有25例复发大肠腺瘤。运用Stata软件对数据进行统计学分析显示相对危险度RR为0.52,可信区间CI:0.29-0.96,P=0.035<0.05,有统计学意义。结论口服大剂量阿司匹林对预防大肠腺瘤术后复发有效。Objective To demonstrate the effect of aspirin on the prevention of colorectal adenomas. Methods Totally150 cases were randomly divided into experimental group（ 75） and control group（ 75）,the experimental group received oral 200 mg / days aspirin,and the control group received placebo. Results After the six months follow up,12 patients recurred the adenoma of the 67 patients who completed the duration of follow up in experimental group,and 25 patients recurred adenoma of the 73 patients who completed the duration of follow up in control group,the RR was 0. 52CI： 0. 29 ~0. 96,P = 0. 035 0. 05. Conclusions Oral high dose aspirin can prevent the recurrence of colorectal adenoma.

关 键 词：阿司匹林 腺瘤性息肉 复发 

分 类 号：R973[医药卫生—药品]