超氧化物歧化酶及其同工酶和超敏C-反应蛋白与冠心病的关系  

Relationship of Superoxide Dismutase Isoenzyme and High Sensitive C-Reactive Protein with Coronary Heart Disease

作　　者：姚创利[1] 黎阳[1] 鲁旭娟 姜小建[1] 

机构地区：[1]西安市中心医院检验科

出　　处：《现代检验医学杂志》2016年第5期73-75,共3页Journal of Modern Laboratory Medicine

基　　金：陕西省科学技术研究发展计划项目(项目编号:2013K12-02-10)

摘　　要：目的：探讨超氧化物歧化酶（T-SOD）及其同工酶锰超氧化物歧化酶（Mn-SOD）活性、超敏C-反应蛋白（hs-CRP）浓度变化与冠心病（CHD）的关系。方法共81例冠心病患者及60例健康体检者参与研究，分别采用比色法和胶乳增强免疫比浊法测定被检者血清T-SOD，Mn-SOD和 H s-CRP。结果和健康对照组相比，冠心病患者组 T-SOD和 Mn-SOD的活性显著降低（t＝9.41，6.34，均P＜0.01），Hs-CRP浓度显著增高，差异有统计学意义（t＝3.09，P＜0.05）；T-SOD，Mn-SOD活性和 H s-CRP浓度呈负相关，差异有统计学意义（P＜0.01）。结论 T-SOD，Mn-SOD和 H s-CRP水平变化与冠心病的发生、发展密切相关，可作为冠心病患者危险因素评估的重要指标，联合检测分析 T-SOD，Mn-SOD和 hs-CRP的相关性对冠心病的临床诊治及预后有一定的指导意义。Objective To investigate the relationship between the activity of superoxide dismutase （T-SOD）as well as its manganese superoxide dismutase isozyme （Mn-SOD）,concentration levels of hypersensitive c-reactive protein（hs-CRP）and coronary heart disease.Methods The levels of serum T-SOD,Mn-SOD and hs-CRP were measured in 81 patients with coro-nary heart disease and 60 healthy controls,respectively.T-SOD was measured by colorimetricmethod and hs-CRP was meas-ured by latex enhanced immune turbidimetric assay.Results Compered with the control group,activity of T-SOD,Mn-SOD in CHD group were significantly decreased （t=9.41,6.34,all P〈0.01）.However,hs-CRP in CHD group were significantly increased to those in controls （t=3.09,P〈0.05）.The activity of T-SOD,Mn-SOD were negatively correlated with hs-CRP （P〈0.01）.Conclusion The variation of T-SOD,Mn-SOD activity and hs-CRP content were closely related to the occur-rence and development of CHD,they could be the impor tant indicators for riskfactors assessment of CHD.Moreover,con-joint analysis the correlation of T-SOD,Mn-SOD and hs-CRP has certain guiding significance for the clinical treatment and prognosis of coronary heart disease.

关 键 词：冠心病 超敏C-反应蛋白 氧化物歧化酶 锰超氧化物歧化酶 

分 类 号：R541.4[医药卫生—心血管疾病] R446.112[医药卫生—内科学]