米非司酮对围绝经期功能失调性子宫出血的疗效观察  

Observation on the curative effect of mifepristone in treatment of perimenopausal dysfunctional uterine bleeding

作　　者：侯宇[1] 

机构地区：[1]广元市中心医院,四川广元628000

出　　处：《中国妇幼保健》2016年第21期4497-4499,共3页Maternal and Child Health Care of China

摘　　要：目的观察米非司酮治疗围绝经期功能失调性子宫出血的临床疗效。方法收集100例围绝经期功能失调性子宫。出血患者，随机分为实验组和对照组，实验组进行诊断性刮宫后给予米非司酮治疗，连用5d后停药，待月经周期的第1天再给予米非司酮，1次／d，连用5d后停药，共治疗3个月经周期。对照组诊断性刮宫后给予米非司酮治疗，1次／d，连用3个月。治疗后观察两组患者月经情况、治疗效果、激素水平、子宫内膜厚度、不良反应及复发率。结果治疗3个月后实验组月经周期恢复正常的患者明显多于对照组（x2=6．894，P=0．016）；治疗3个月后实验组患者的临床疗效明显高于对照组（x2=4．817，P=0．032）；治疗3个月后两组患者的激素水平均比治疗前明显降低（P〈0．05），但实验组患者降低的更明显（P〈0．05）；治疗3个月后两组患者的子宫内膜均明显薄于治疗前，但实验组患者更薄（P〈0．05）；两组患者的不良反应均很轻，且两组患者的不良反应及复发率均没有统计学差异（P〉0．05）。结论米非司酮治疗围绝经期功能失调性子宫出血的疗效显著，而米非司酮周期疗法治疗围绝经期功能失调性子宫出血的效果显著，在临床工作中值得大力推广。Objective To observe the clinical curative effect of mifepristone in treatment of perimenopausal dysfunctional uterine bleed- ing. Methods One hundred patients with perimenopausal dysfunctional uterine bleeding were collected and randomly divided into experi- mental group and control group. The patients in experimental group were treated by mifepristone after diagnostic curettage for consecutive five days, then the treatment continued for consecutive five days from the first day of menstruation cycle, the treatment lasted 3 menstrual cycles. The patients in control group were treated by mifepristone after diagnostic curettage, once a day for 3 months. After treatment, menstruation situations, curative effects, hormones levels, endometrial thicknesses, adverse reactions, and recurrence rates in the two groups were ob- served. Results The number of patients whose menstrual cycle returned to normal in experimental groupwas significantly more than that in control group after treatment of three months. The clinical curative effect in experimental group was significantly better than that in control group after treatment of three months. The hormones levels in the two groups after treatment of three months were significantly lower than those before treatment, especially in experimental group. Endometrial thicknesses in the two groups after treatment of three months were sig- nificantly thinner than those before treatment, especially in experimental group. The adverse reactions in the two groups were mild, andthere was no statistically significant difference in adverse reactions and recurrence rate between the two groups （P〉0.05 ） . Conclusion The clinical curative effect of mifepristone in treatment of patients with perimenopausal dysfunctional uterine bleeding is significant, and the clini- cal curative effect of mifepristone cycle therapy is more significant, which is worthy of promotion and application in clinical work.

关 键 词：米非司酮 围绝经期 子宫出血 失调 

分 类 号：R711.51[医药卫生—妇产科学]