妊娠期慢性乙型肝炎病毒携带者病毒载量与妊娠期糖尿病的相关性  

Association between viral load and gestational diabetes mellitus in women with chronic hepatitis B

作　　者：李飞凤[1] 黄启涛[1] 黄晨[2] 周元平[2] 刘志华[2] 曾文娟[1] 王海臻[1] 袁国盛 钟梅[1] 高云飞[1] 

机构地区：[1]南方医科大学南方医院妇产科,广州市510515 [2]南方医科大学南方医院感染内科,广州市510515

出　　处：《实用医学杂志》2016年第19期3117-3119,共3页The Journal of Practical Medicine

基　　金：国家自然科学青年基金(编号:81401208);广东省医学科研基金(编号:A2016524)

摘　　要：目的：分析慢性乙型肝炎病毒（HBV）携带孕妇病毒载量与妊娠期糖尿病（GDM）的关系。方法：按HBV DNA 是否≥1．0＆#215;103 IU／mL 分为：HBV DNA（＋）组161例及 HBV DNA（－）组175例；并选取同时期非HBV携带孕妇409例作对照组。分别比较各组孕妇GDM发生率的差异及分析病毒载量与OGTT血糖水平的相关性。结果：HBV DNA（＋）组、（－）组GDM发生率分别为16．77％和17．71％，均明显高于非HBV携带组的10．27％，差异有统计学意义（P ＜0．05）。 HBV DNA与空腹血糖水平相关系数r ＝0．005， P ＝0．610，差异无统计学意义；但与服糖后1、2 h 血糖水平相关系数分别为 r ＝0．082，0．086；P ＝0．000，0．000，差异有统计学意义。结论：慢性HBV携带孕妇GDM发生率增加，HBV DNA载量与服糖后1、2 h 血糖水平呈正相关。Objective To analyze the GDM of 336 cases with chronic HBV in pregnancy. Methods According to HBV DNA≥1.0 ＆#215; 103 IU/mL, participants were divided into HBV DNA （＋） or （-） group. 409 cases without HBV were selected as control group. Differences on GMD incidence between groups and virus load and OGTT blood sugar correlation were compared. Results The incidence of GDM of HBV DNA （＋） or （-） group was 16.77% and 17.71%, which is higher than that in HBV group （10.27%）. The difference is significant （P 〈 0.05）. The correlation index between HBV DNA and fasting blood-glucose is r = 0.005, P = 0.610, the result of which is not statistically significant. But correlation index between HBV DNA and blood sugar at 1 h , 2 h are r = 0.082, 0.086; P = 0.000, 0.000, the result of which is statistically significant. Conclusion The oc-currence of GDM were higher in HBV DNA （＋） or （-） group. The viral load is positively related with blood sugar of glucose tolerance at 1 h or 2 h.

关 键 词：乙型肝炎 孕妇 病毒载量 妊娠期糖尿病 

分 类 号：R714.25[医药卫生—妇产科学]