造血干细胞移植后淋巴增殖性疾病在颈胸部的影像学分析  

Analysis of Imaging Features Post-Transplantation Lymphoproliferative Disorder In the Neck and Chest After Allogenic Hemopoietic Stem Cell Transplantation and Literature Review

作　　者：杨硕[1] 霍天龙[1] 赖云耀[1] 郝传玺[1] 刘晓怡[1] 

机构地区：[1]北京大学人民医院放射科,100044

出　　处：《临床放射学杂志》2016年第10期1513-1517,共5页Journal of Clinical Radiology

摘　　要：目的探讨造血干细胞移植后患者并发移植后淋巴增殖性疾病(PTLD)的颈胸部的影像学表现。方法回顾分析2217例行异基因造血干细胞移植住院患者的影像学表现。经病理诊断PLTD累及颈胸部者共16例,分别行颌面部MRI、CT、胸部CT以及PET/CT,分析病变影像特征。结果累及咽部者4例,表现为咽部肿块并中央坏死;肺部3例,肺内团块影,界清,偶伴磨玻璃影;乳腺2例,乳腺结节影,PET/CT呈高代谢表现;仅淋巴结肿大7例。结论造血干细胞移植后的PTLD可累及淋巴结及结外组织,颈胸部的影像学检查,尤其PET/CT在早期发现病变、鉴别诊断、指导活检部位及监测疗效等方面具有重要价值。Objective To investigate the imaging features of post-transplantation lymphoproliferative disorder（ PTLD）in the neck and chest after allogenic hemopoietic stem cell transplantation. Methods A retrospective analysis of the maxillofacial MRI and CT; chest CT and PET / CT findings was performed in patients（ n = 16） with pathologically proven PTLD after allogenic bone marrow transplantation from January 2011 to September 2015. Results The imaging features of PTLD patients included pharyngeal tumor with necrosis（ n = 4）,well-defined lung nodules（ n = 3）,non-necrotic,occasionally ground glass,lymphadenopathy only（ n = 7）,breast tumor（ n = 2） with high FDG uptake. Conclusion PTLD can involve various parts of the body,including lymph nodes and extranodal tissues. Imaging examination,especially PET / CT,allow the diagnosis at an early stage,differential diagnosis,guiding tissue sampling and evaluating response to the treatment of PTLD.

关 键 词：造血干细胞移植 移植后淋巴增殖性疾病 颈部 肺 乳腺 PET/CT 

分 类 号：R457.7[医药卫生—治疗学]