夜间遗尿症儿童fMRI半球间同伦的功能研究  

The Functional Research of Voxel-Mirrored Homotopic Connectivity of Children with Nocturnal Enuresis by Functional Magnetic Resonance Imaging

作　　者：江凯华[1] 丁丽[1] 李红新[1] 丁立[1] 高敏[1] 易阳[1] 吴婷[1] 郑爱斌 

机构地区：[1]江苏省常州市儿童医院儿童健康研究中心,213003

出　　处：《临床放射学杂志》2016年第10期1577-1580,共4页Journal of Clinical Radiology

基　　金：江苏省科技专项(编号:BL2014037)

摘　　要：目的采用静息态功能磁共振成像(rs-f MRI)半球间同伦(VMHC)方法研究夜间遗尿症(NE)儿童功能受损脑区的特征。方法选取NE与正常儿童各15名分别进行rs-f MRI扫描,采用VMHC的方法进行分析,并通过双样本t检验比较两组VMHC值的差异。结果组间VMHC值比较有明显差异的脑区位于小脑和前扣带回(P<0.05,校正后),均为NE组低于正常组。结论 NE患儿两半球小脑间的功能连接强度降低使小脑定时功能受损,出现控制排尿障碍,同时NE小脑功能异常可能与其注意力下降有关;前扣带回间功能连接减弱使接收排尿信号的能力下降,表现为遗尿症状。Objective To research the characteristics of impaired brain regions of children with nocturnal enuresis（ NE） by voxel-mirrored homotopic connectivity（ VMHC） of resting-state functional magnetic resonance imaging（ rs-f MRI）. Methods Use the approach of voxel-mirrored homotopic connectivity（ VMHC） to analyze 15 NE children and normal children,both of whom had been examined by rs-f MRI scans. Then compare the difference of VMHC between by two samples T-TEST. Results The brain regions,which had obvious differences of VMHC between the two groups,were cerebellum and anterior cingulate gyrus. The group of NE was lower than normal children on both two regions. Conclusion The decreasing of the intensity of functional connection between cerebellums on children with NE damages cerebellum＇s timing function and causes dysfunction of controlling urination. Meanwhile,cerebellar dysfunction may be related to the decline of concentration and the decreasing of the intensity of the anterior cingulate gyrus connections decreases the ability of receiving the signal of urination and manifests as enuresis.

关 键 词：夜间遗尿症 静息态功能磁共振成像 半球间同伦 

分 类 号：R726.9[医药卫生—儿科] R445.2[医药卫生—临床医学]