某院抗肿瘤药物不良反应的影响因素分析  

Analysis of the Influencing Factors of ADR Induced by Antitumor Drugs

作　　者：郑瑜[1] 朱志伟[1] 郑志伟[1] 邱国栋[1] 

机构地区：[1]汕头大学医学院附属肿瘤医院,广东汕头515041

出　　处：《肿瘤药学》2016年第5期393-397,共5页Anti-Tumor Pharmacy

基　　金：2015年汕头市医疗科技计划项目[汕府科(2015)123号]

摘　　要：目的总结某院抗肿瘤药物不良反应（ADR）发生的情况及影响因素,为临床安全用药提供参考。方法收集某院2011年1月~2015年12月上报的325例涉及抗肿瘤药物的ADR报告,分别从患者的性别与年龄、药物类别、所累及器官或系统及临床表现等方面进行统计和分析。结果 325例ADR中,男性169例,女性156例;40岁以上中老年患者较多,占89.54%;涉及抗肿瘤药物9大类46种;以皮肤及其附件损害最为常见,占32.02%;静脉滴注的ADR最多,占89.54%。抗肿瘤药物ADR的影响因素有：年龄、病史、治疗史、用药途径等。结论临床药师应根据抗肿瘤药物ADR相关风险因素对患者进行全面药学监护以保障用药安全。Objective To analyze the characteristics and the influencing factors of adverse drug reactions（ADR） induced by antitumor drugs in a hospital and to provide references for clinical safe use of antitumor drugs. Methods The clinical data of 325 cases with ADR of antitumor drugs were collected from Jan. 2011 to Dec. 2015 in the hospital. The age and sex, kinds of drugs, ADR-involved organs or systems and clinical manifestations were analyzed of all cases. Results In all of the 325 ADR cases, 169 were male and 156 were female. The incidence of ADR occurred in the patients over 40 years old was 89.54%. Nine categories（46 kinds） of drugs were involved. The damage to skin and appendant was the most common adverse reaction, accounting for 32.02%. Among the 325 ADR cases, 89.54% of them had their antitumor drugs infused intravenously. The influencing factors included age, previous medical history, treatment history and medication route. Conclusion To ensure safe use of drugs, clinical pharmacists should take comprehensive pharmaceutical care on patients based on the related risk factors of ADR induced by antitumor drugs.

关 键 词：抗肿瘤药物 药物不良反应 影响因素 安全用药 

分 类 号：R9[医药卫生—药学]