机构地区:[1]昆明医科大学第一附属医院产科,650032 [2]昆明医科大学第一附属医院儿科,650032
出 处:《中华妇产科杂志》2016年第10期748-753,共6页Chinese Journal of Obstetrics and Gynecology
摘 要:目的探讨剖宫产术后再次妊娠阴道试产(TOLAC)孕妇的妊娠结局。方法2013年7月至2016年6月昆明医科大学第一附属医院共实施TOLAC614例,回顾性分析其中既往有1次剖宫产术史、单活胎、孕周/〉28周的586例TOLAC孕妇的临床资料,并根据分娩方式分为TOLAC成功者[即剖宫产术后再次妊娠阴道分娩(VBAC)组]481例,TOLAC失败中转剖宫产者(TOLAC失败组)105例;另选取同期剖宫产术后再次妊娠(孕周I〉28周、单活胎、1次剖宫产术史)直接行选择性再次剖宫产术(ERCS)者(ERCS组)1145例作为对照。比较3组不同分娩方式孕妇的妊娠结局,并采用多元logistic回归分析3组新生儿入住新生儿ICU(NICU)治疗的独立危险因素。结果(1)研究期间本院分娩的孕周I〉28周孕妇共16112例(其中有剖宫产史者2073例),共实施TOLAC614例,其中VBAC507例;总TOLAC率为29.62%(614/2073),VBAC率为82.6%(507/614),VBAC降低了同期总剖宫产率3.147%(507/16112)。(2)妊娠结局的比较:VBAC组孕妇的产后出血量为(431±299)ml,产后发热率为6.4%(31/481),新生儿出生体质量为(3085±561)g,大于胎龄儿率为2.9%(14/481),均低于TOLAC失败组和ERCS组(P〈0.05)。VBAC组的子宫破裂率为0.2%(1/481)、膀胱损伤率为0、产后出血/〉1500ml的发生率为1.0%(5/481)、输血率为3.7%(18/481),分别与TOLAC失败组和ERCS组比较,差异均无统计学意义(P〉0.05)。(3)新生儿结局的比较:VBAC组新生儿5分钟Apgar评分〈7分的发生率为0.4%(2/481)、脐动脉血pH〈7.0的发生率为0.6%(3/481)、转NICU率为12.3%(59/481)、围产儿死亡率为0,与TOLAC失败组和ERCS组分别比较,差异均无统计学意义(P〉0.05)。新生儿人住NICU治疗的独立危险因素依次为:早产(OR=16.71,95%CI为1Objective To explore the outcome of trial of labor after cesarean section (TOLAC). Methods Totally 614 TOLAC were conducted in the First Affiliated Hospital of Kunming Medical University from July 2013 to June 2016. Among them, 586 cases of singleton pregnancy with one prior cesarean section (gestational age≥28 weeks) were studied retrospectively. The maternal and neonatal outcomes among the vaginal birth after cesarean (VBAC) group (481 cases), failed TOLAC group (105 cases) and the elective repeat cesarean section (ERCS) group (1 145 cases) were compared. Multiple logistic regression was used to determine the risk factors of admission to neonatal intensive care unit (NICU). Results (1) The TOLAC rate was 29.62% (614/2 073) from July 2013 to June 2016, and the VBAC rate was 82.6% (507/614). The cesarean section rate was reduced by VBAC by 3.147%(507/16 112). (2) The comparison of adverse maternal outcomes: in the VBAC group, the postpartum hemorrhage volume was (431±299) ml, the rate of postpartum fever was 6.4% (31/481), the birth weight of the neonates was (3 085± 561 ) g, and the rate of large for gestational age was 2.9%( 14/481 ). All were significantly lower than those in the failed TOLAC group and the ERCS group (P〈0.05). There was no significant difference in other adverse maternal outcomes[the uterine rupture rate (0.2% ,1/481), the bladder injury rate (0), the proportion of postpartum hemorrhage volume≥1 500 ml (1.0%, 5/481 ), the blood transfusion rate (3.7%, 18/481)] and adverse perinatal outcomes [the rate of neonatal 5-minute Apgar score〈7 (0.4%, 21/481), the rate of umbilical arterial pH〈7.0 (0.6%, 3/481), the rate of the NICU admission and the perinatal mortality rate (12.3%, 59/481 )] among the 3 groups (P〉0.05). Multiple logistic regression showed no association between VBAC and admission to the NICU (OR=0.84, 95%CI: 0.58-1.21). The isolated risk factors for admission to
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