中药多糖在抗肿瘤免疫中的研究进展  

The research progress of anti-tumor immunity of Chinese medicine polysaccharides

作　　者：郑昱婧 宋淑亮[1,2] 梁浩[1,2] 吉爱国[1,2,3] 

机构地区：[1]山东大学(威海)海洋学院,264209 [2]山东大学威海国际生物技术研发中心,威海264209 [3]山东大学药学院,济南250012

出　　处：《生命的化学》2016年第5期601-606,共6页Chemistry of Life

摘　　要：近年来,中药多糖由于其显著的免疫调节作用,抗肿瘤活性以及低毒高效性,而受到学者和消费者的广泛关注,可作为一类理想的抗肿瘤免疫的营养药物。本文主要对中药多糖的对肿瘤微环境的免疫调节作用,对免疫的双向调节作用,作为化疗药免疫佐剂的潜在应用价值以及通过口服途径发挥免疫调节作用的机制等方面进行了综述。这都将为中药多糖在抗肿瘤免疫中的潜在应用提供理论依据。Nowadays, Chinese medicine polysaccharides, which has drawn increasing attention from researchers and consumers due to its obvious immunomodulating and antitumor activities, as well as the relatively low toxicity of the polysaccharides. It could be used as a kind of ideal nutraceuticals for anti-tumor immunity. In this review, we have introduced the Chinese medicine polysaccharides according to the immunomodulatory effects in tumor microenvironment, the bidirectional immunomodulatoryactivities, the potential for its development as adjuvant for chemotherapy drugs, as well as the mechanisms on its immunomodulatory effect by oral administration.The review will provide theoretic foundation on the potential application of antitumor immunity.

关 键 词：中药多糖 抗肿瘤免疫 营养药物 肿瘤微环境 双向调节 免疫佐剂 口服途径 

分 类 号：R285[医药卫生—中药学]