血小板源性CXC-型趋化因子在动脉粥样硬化中的作用  

The role of platelet-derived CXC-chemokines in atherosclerosis

作　　者：王晓微[1] 张蕾 许丽辉[1] 贺文[1] 

机构地区：[1]河北医科大学基础医学院生物化学与分子生物学教研室河北省医学生物技术重点实验室,石家庄050000 [2]河北省血液中心,石家庄050000

出　　处：《生命的化学》2016年第5期621-624,共4页Chemistry of Life

摘　　要：近年来动脉粥样硬化在我国逐渐增多,该病是动脉硬化的血管病中最重要的一种,是心肌梗塞和脑梗塞的主要病因,也是中老年人死亡的主要原因之一。在我国已经证实,血小板源性的趋化因子——尤其是CXC-型趋化因子在动脉粥样硬化形成中发挥重要作用。因此,了解趋化因子的作用机制,可以为临床治疗动脉粥样硬化提供新的思路以及治疗靶点。In recent years, atheroscleros is gradually increased in our country. The disease is the most important kind of atherosclerotic vascular diseases, and is the main cause of myocardial infarction and cerebral infarction race. And it also is one of the leading causes of death in the elderly. It has been confirmed in our country that platelet-derived chemokines, especially the CXC-chemokines play an important role in atherosclerosis. Therefore, understanding the mechanism of the chemokines can offer new ideas for clinical treatment of atherosclerosis as well as therapeutic targets.

关 键 词：血小板 趋化因子 动脉粥样硬化 作用 

分 类 号：R543.5[医药卫生—心血管疾病]