维生素D与病毒性肝炎  

Vitamin D and viral hepatitis

作　　者：周衍衡[1,2] 陈延平[3] 徐光华[3] 白占涛[1,2] 

机构地区：[1]延安大学生命科学学院/多肽资源药物研究中心,延安716000 [2]陕西省区域生物资源保育与利用工程技术研究中心,延安716000 [3]延安大学附属医院,延安716000

出　　处：《生命的化学》2016年第5期666-670,共5页Chemistry of Life

基　　金：陕西省教育厅专项科研计划项目(14JK1834);延安大学博士科研项目(YDBK2013-2);陕西省高水平大学建设专项资金资助项目(2012SXTS06)

摘　　要：病毒性肝炎仍为常见多发的感染性疾病。维生素D是人体必需的一种固醇类衍生物,参与调节钙磷吸收、免疫与抗炎、细胞增殖与分化等重要生命活动。新近发现,病毒性肝炎患者维生素D普遍缺乏,维生素D又具抗病毒作用,凸显出维生素D与病毒性肝炎的正相关性。本文综述维生素D的代谢补偿途径、受体信号通路与病毒性肝炎发生的分子机制,拟构建基于维生素D的病毒性肝炎发生、诊疗新策略和新方法。Viral hepatitis is still a common infectious disease with high frequency at present. Vitamin D, an essential derivative of steroid, plays a major role in calcium and phosphate homeostasis and is also involved many life activities such as immune responses, anti-inflammatory, cellular proliferation and differentiation. Recently, vitamin D deficiency has been identified to be a common feature of viral hepatitis. Besides, vitamin D has anti-HCV activity in vitro. These results strongly indicated there is a positive association between vitamin D and viral hepatitis. In this review, we have summarized the molecular mechanisms of vitamin D, its metabolisms effecting on viral hepatitis, as well as vitamin D/vitamin D receptor signal pathway. We hope this review could provide theoretical clues for making novel prognostic and treatment strategies in viral hepatitis based on vitamin D.

关 键 词：维生素D 病毒性肝炎 相关性 

分 类 号：R512.6[医药卫生—内科学]