复方樟柳碱联合维生素B12对长期服用二甲双胍糖尿病视神经病变患者疗效观察  

Clinical study of compound Anisodine combined with vitamin B12 in treating diabetic optic neuropathy patients with long-term use of metformin

作　　者：孙世龙[1] 张英杰[2] 张颖[2] 高延庆[3] 张慧芝[2] 王贝贝[3] 徐磊[4] 

机构地区：[1]郑州市第二人民医院神经内科,郑州450006 [2]郑州市第二人民医院药务科,郑州450006 [3]郑州市第二人民医院眼科,郑州450006 [4]郑州市第二人民医院内分泌科,郑州450006

出　　处：《中国实用眼科杂志》2016年第10期1090-1093,共4页Chinese Journal of Practical Ophthalmology

基　　金：2014年郑州市“临床药学科研基金”立项科研项目（CCSYJJ14013）

摘　　要：【摘要】目的观察复方樟柳碱注射液和维生素B12注射液联合应用对长期服用二甲双胍的2型糖尿病视神经病变患者的临床效果。方法选取2015年1～12月来郑州市第二医院进行治疗的长期服用二甲双胍的2型糖尿病视神经病变患者（186例）为研究对象，将其随机分为对照组（93例）和观察组（93例），测定患者血清维生素B12水平。在服用二甲双胍控制血糖的基础上，对照组使用复方樟柳碱注射液2ml颞浅动脉旁皮下注射，观察组给予复方樟柳碱注射液2ml和维生素B12注射液0．2ml混合液患眼颞浅动脉旁皮下注射。两组均一天一次，14d为—个疗程，治疗3个疗程。比较对照组和观察组对患者视力、视野和视网膜神经纤维层厚度的改善情况，并观察复方樟柳碱联合维生素B12治疗糖尿病视神经病变的安全性。结果对照组和观察组的总有效率分别为56％和78．6％，差异具有统计学意义（P〈0．05），未见不良反应发生。结论复方樟柳碱联合维生素B12对长期服用二甲双胍糖尿病视神经病变患者较单纯复方樟柳碱的疗效显著。Objective To investigate clinical results of compound anisodine combined with vita- min B12 for type 2 diabetes optic neuropathy patients with long-term use of metformin. Methods From January 2015 to December 2015, 186 cases of type 2 diabetes optic neuropathy with long-term use of metformin admitted to the outpatients in our hospital for the clinical study and were randomly divided into control group （93 cases） and observation group （93 cases）, serum vita- min B12 levels were determined. On the basis of taking metformin for controlling blood glucose, the control group was treated with the compound anisodine 2ml subcutaneous injection beside the affect- ed side arteriae temporalis superficialis and the observation group was treated with the mixture of the compound anisodine 2ml and vitamin B,： 0.2ml subcutaneous injection beside the affected side ar- teriae temporalis superficialis. The both groups were once a day and the period of treatment were three courses （two weeks for one course）. After three courses of treatment, visual acuity, field of vi- sion and retinal nerve fiber layer thickness changes of two groups were compared and the security of the compound anisodine combined with vitamin B12 for diabetes optic neuropathy were observed. Results After treatment, total effective rate of the control group and observation group were 56% and 78.6% respectively, and the difference was statistically significant （P 〈0.05）. During treatment, it showed no significant adverse reactions. Conclusions The clinical results of comnound anisodine combined with vitamin B12 are more significant than the compound anisodine only for type 2 diabe- tes optic neuropathy patients with long-term use of metformin.

关 键 词：复方樟柳碱 维生素B12 二甲双胍 糖尿病视神经病变 

分 类 号：R657.18[医药卫生—外科学]