清咽利肺散剂的止咳、化痰、抗炎和止痛作用研究  

Study on the Effects of Relieving Cough,Reducing Phlegm,Inhibiting Inflammatory and Relieving Pain of Qingyan Lifei Powder

作　　者：张丽[1] 张一云[2] 符洪[2] 王开裕[1] 雷玲芳[1] 王春桃[2] 

机构地区：[1]海南省中医院药学部,海口570203 [2]海南省药物研究所,海口570216

出　　处：《中国药房》2016年第31期4376-4378,共3页China Pharmacy

基　　金：海南省中药现代化专项项目(No.ZY201428)

摘　　要：目的:考察清咽利肺散剂的止咳、化痰、抗炎和止痛作用。方法:将小鼠分为模型组、阳性对照组(炎见宁片,0.29 g/kg)和清咽利肺散剂低、中、高剂量组(13.7、27.3、54.6 g/kg),每组10只。模型组小鼠ig等体积生理盐水,各给药组小鼠ig相应药物,每天1次,连续7 d。给药结束后,分别采用小鼠氨水引咳实验、气管酚红排泌实验、二甲苯致耳肿胀实验和醋酸扭体实验考察清咽利肺散剂的止咳、化痰、抗炎、止痛作用。结果:与模型组比较,除清咽利肺散剂低剂量组小鼠外,其余各组小鼠的咳嗽次数均明显减少,且清咽利肺散剂高剂量组小鼠的咳嗽潜伏期明显延长(P<0.05或P<0.01);阳性对照组和清咽利肺散剂高剂量组小鼠的酚红排泌量、20 min内扭体次数明显减少,耳肿胀度明显减轻(P<0.05或P<0.01)。结论:清咽利肺散剂对小鼠具有良好的止咳、化痰、抗炎、消肿止痛的作用。OBJECTIVE： To investigate the effects of Qingyan lifei powder （QYLFP）on relieving cough, reducing phlegm, inhibiting inflammatory and relieving pain. METHODS： The mice were divided into model group, positive control group （Yanjianning tablet, 0.29 g/kg）, QYLFP low-dose, medium-dose and high-dose groups （13.7, 27.3, 54.6 g/kg）, with 10 mice in each group. Model group was given constant volume of normal saline intragastrically, and treatment groups were given relevant medicine intragastrically, once a day, for 7 days. After medication, the effects of relieving cough, reducing phlegm, anti-inflammatory and analgesic of QYLFP were investigated through ammonia-induced cough method, phenol red method, xylene-caused mice ear edema test and acetic acid writhing test. RESULTS： Compared with model group, the cough times of those groups decreased significantly, except for QYLFP low-dose group; the cough incubation period in QYLFP high-dose group prolonged significantly （P〈 0.05 or P〈0.01）. The phenol red excretion amount and writhing times within 20 min of mice decreased significantly and ear edema relieved significantly in positive control and QYLFP high-dose group （P〈0.05 or P〈0.01）. CONCLUSIONS： QYLFP has good effects on relieving acough, reducing sputum and inhibiting inflammatory and relieving pain.

关 键 词：清咽利肺散剂 止咳 化痰 消炎 止痛 小鼠 

分 类 号：R943[医药卫生—药剂学]