Light weight, mechanically strong and biocompatible α-chitin aerogels from different aqueous alkali hydroxide/urea solutions  

作　　者：Beibei Ding Dan Zhao Jianhui Song Huichang Gao Duoduo Xu Min Xu Xiaodong Cao Lina Zhang Jie Cai 

机构地区：[1]College of Chemistry & Molecular Sciences, Wuhan University [2]Key Laboratory of Rubber-Plastics, Ministry of Education Shandong Provincial Key Laboratory of Rubber-Plastics,Qingdao University of Science & Technology [3]Department of Physics, Shanghai Key Laboratory of Magnetic Resonance, East China Normal University [4]School of Materials Science and Engineering, South China University of Technology

出　　处：《Science China Chemistry》2016年第11期1405-1414,共10页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China (21422405, 51373125);the Major Program of National Natural Science Foundation of China (21334005);the facility support of the Natural Science Foundation of Hubei Province;the Fundamental Research Funds for the Central Universities

摘　　要：Light weight and mechanically strong α-chitin aerogels were fabricated using the sol-gel/self-assembly method from α-chitin in different aqueous alkali hydroxide(KOH, Na OH and Li OH)/urea solutions. All of the α-chitin solutions exhibited temperature-induced rapid gelation behavior. 13 C nuclear magnetic resonance(NMR) spectra revealed that the aqueous alkali hydroxide/urea solutions are non-derivatizing solvents for α-chitin. Fourier transform infrared(FT-IR), X-ray diffraction(XRD) and cross-polarization magic angle spinning(CP/MAS) 13 C NMR confirmed that α-chitin has a stable aggregate structure after undergoing dissolution and regeneration. Subsequently, nanostructured α-chitin aerogels were fabricated by regeneration from the chitin solutions in ethanol and then freeze-drying from t-Bu OH. These α-chitin aerogels exhibited high porosity(87% to 94%), low density(0.09 to 0.19 g/cm^3), high specific surface area(419 to 535 m^2/g) and large pore volume(2.7 to 3.8 cm^3/g). Moreover, the α-chitin aerogels exhibited good mechanical properties under compression and tension models. In vitro studies showed that m BMSCs cultured on chitin hydrogels have good biocompatibility. These nanostructured α-chitin aerogels may be useful for various applications, such as catalyst supports, carbon aerogel precursors and biomedical materials.Light weight and mechanically strong α-chitin aerogels were fabricated using the sol-gel/self-assembly method from α-chitin in different aqueous alkali hydroxide（KOH, Na OH and Li OH）/urea solutions. All of the α-chitin solutions exhibited temperature-induced rapid gelation behavior. 13 C nuclear magnetic resonance（NMR） spectra revealed that the aqueous alkali hydroxide/urea solutions are non-derivatizing solvents for α-chitin. Fourier transform infrared（FT-IR）, X-ray diffraction（XRD） and cross-polarization magic angle spinning（CP/MAS） 13 C NMR confirmed that α-chitin has a stable aggregate structure after undergoing dissolution and regeneration. Subsequently, nanostructured α-chitin aerogels were fabricated by regeneration from the chitin solutions in ethanol and then freeze-drying from t-Bu OH. These α-chitin aerogels exhibited high porosity（87% to 94%）, low density（0.09 to 0.19 g/cm^3）, high specific surface area（419 to 535 m^2/g） and large pore volume（2.7 to 3.8 cm^3/g）. Moreover, the α-chitin aerogels exhibited good mechanical properties under compression and tension models. In vitro studies showed that m BMSCs cultured on chitin hydrogels have good biocompatibility. These nanostructured α-chitin aerogels may be useful for various applications, such as catalyst supports, carbon aerogel precursors and biomedical materials.

关 键 词：chitin aerogels alkali hydroxide/urea aqueous solutions mechanical properties biocompatibility 

分 类 号：TQ427.26[化学工程] TQ441.41