猴腿蹄盖蕨根茎化学成分及其还原能力  

Chemical Constituents from Athyrium multidentatum Rhizome and Their Reducing Capacity

作　　者：刘冬梅[1] 盛继文[1] 王思宏[2] 张维芬[1] 张晓红[1] 王得运[1] 

机构地区：[1]潍坊医学院药学院,山东潍坊261053 [2]延边大学分析测试中心,吉林延吉133002

出　　处：《中国实验方剂学杂志》2016年第21期59-62,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81573717;21365023);山东省自然科学基金项目(ZR2013HQ024);山东省中医药科技发展计划项目(2015-230)

摘　　要：目的:研究猴腿蹄盖蕨Athyrium multidentatum根茎化学成分并测定各成分的还原能力。方法:利用硅胶柱色谱技术分离纯化化学成分,结合理化性质及波谱数据鉴定化合物的结构。采用紫外-可见分光光度法测定化合物的还原能力。结果:得到11个化合物,分别为亚油酸甲酯(1),大黄素甲醚(2),二十四碳酸(3),正二十六烷醇(4),亚油酸(5),β-谷甾醇(6),胡萝卜苷(7),striatisporolide A(8),原儿茶酸甲酯(9),原儿茶酸(10)及D-葡萄糖(11)。结论:除化合物3和6,其他化合物均为首次从猴腿蹄盖蕨中分离得到。化合物9,10具有较强的还原能力。Objective： To study the chemical constituents from rhizome of Athyrium multidentatum and their reducing capacity. Method： The chemical constituents were separated and purified by silica-gel column chromatography,and identified according to physicochemical properties and spectral data. The reducing capacity was detected by ultraviolet-visible spectrophotometry. Result： Eleven compounds were obtained from A. multidentatum rhizome and identified as methyl linoleate（ 1）, physcion（ 2）, tetracosanoic acid（ 3）,1-hexacosanol（ 4）,linoleic acid（ 5）,β-sitosterol（ 6）,daucosterol（ 7）,striatisporolide A（ 8）,protocatechuic acid methyl ester（ 9）,protocatechuic acid（ 10） and D-glucose（ 11）. Conclusion： Except for compounds 3 and6,all of the remaining compounds were prepared from A. multidentatum for the first time,and compounds 9 and 10 showed a notable reducing capacity.

关 键 词：猴腿蹄盖蕨 大黄素甲醚 striatisporolide A 还原能力 

分 类 号：R284.1[医药卫生—中药学]