油田工人5-HT2A受体基因多态性与职业应激易感性的相关性研究  

Association between 5-hydroxytryptamine 2A receptor gene polymorphisms and susceptibility to occupational stress in oilfield workers

作　　者：姜雨[1] 帕丽扎提·阿布都热依木 高晓燕[1] 关素珍[1] 刘继文[1] 

机构地区：[1]新疆医科大学公共卫生学院劳环教研室,乌鲁木齐830054 [2]新疆医科大学第一附属医院检验中心

出　　处：《中华劳动卫生职业病杂志》2016年第10期742-745,共4页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：国家自然科学基金（81460489）;新疆维吾尔自治区研究生科研创新项目（XJGRI2015068）

摘　　要：目的 探讨油田工人5-羟色胺（5-HT）2A受体基因多态性与职业应激的关系.方法 于2013年1至8月,采用整群抽样的方法抽取826名油田工人,采用单核苷酸多态性分析技术测定5-HT2A受体基因rs6313、rs1923884以及rs2070040位点的基因型,采用职业应激量表（OSI-R）分析研究对象职业应激状况.结果 不同个体特征职业应激程度组比较差异均无统计学意义（均P＞0.05）.5-HT2A受体各多态性位点不同基因型职业应激得分的比较,rs6313位点任务冲突得分CC和CT基因型高于TT基因型（均P＜0.05）,业务紧张反应得分CC基因型高于CT基因型（P＜0.05）;rs1923884位点职业任务得分CT基因型高于CC基因型（RO.05）,个体应对资源得分CT基因型高于CC和TT基因型（均P＜0.05）;rs2070040位点业务紧张反应得分AG基因型高于AA基因型（P＜0.05）.有序多分类logistic回归分析结果显示,rs1923884位点CT基因型的个体可能具有职业应激易感性（OR=1.56,95％CI：1.10～2.20）.结论 油田工人5-HT2A受体rs1923884位点CT基因型可能与职业应激易感性有关.Objective To investigate the association between 5-hydroxytryptamine 2A（5-HT2A） receptor gene polymorphisms and occupational stress in oilfield workers.Methods Cluster sampling was used to select 826 oilfield workers from January to August,2013.The SNaPshot single nucleotide polymorphism （SNP） genotyping method was used to determine the genotypes of rs6313,rs1923884,and rs2070040 in 5-HT2A receptor gene,and the Occupational Stress Inventory-Revised Edition was used to analyze occupational stress in these workers.Results There were no significant differences in occupational stress between groups with different individual characteristics （P〉0.05）.As for the comparison of occupational stress scores between workers with different genotypes of each SNP of 5-HT2A receptor gene,the workers with CC and CT genotypes of rs6313 had significantly higher role boundary scores than those with TT genotype （P〈O.05）,and the workers with CC genotype had a significantly higher vocational stress score than those with CT genotype （P〈0.05）;the workers with CT genotype of rs1923884 had a significantly higher occupational role score than those with CC genotype （P〈 0.05） and a significantly higher coping resources score than those with CC and TT genotypes （P〈0.05）;the workers with AG genotype of rs2070040 had a significantly higher vocational stress score than those with AA genotype （P〈0.05）.The ordinal multinomial logistic regression analysis showed that workers with CT genotype of rs1923884 were susceptible to occupational stress （OR=1.56,95%CI 1.10～2.20）.Conclusion CT genotype of rs1923884 in 5-HT2A receptor gene may be associated with the susceptibility to occupational stress in oilfield workers.

关 键 词：职业应激 5-HT2A受体基因 多态性 易感性 

分 类 号：R13[医药卫生—劳动卫生]