不同中药制剂治疗骨质疏松的临床观察  

Different Treatments for Osteoporosis with Traditional Chinese Medicine

作　　者：邬波[1] 柳椰[1] 马旭[1] 翟良全 杜明昌[1] 谭成波[1] 杨政博 付恂 

机构地区：[1]沈阳市骨科医院关节外科,辽宁沈阳110044

出　　处：《中华中医药学刊》2016年第11期2567-2569,共3页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的：观察琥珀丸和壮骨片治疗骨质疏松症的，临床疗效。方法：选取180例骨质疏松症患者，随机分为对照组、琥珀丸组和壮骨片组各60例，对照组以常规药物口服钙尔奇-D片进行治疗，琥珀丸组和壮骨片组分别在此基础上加用琥珀丸和壮骨片，3组均连续治疗3个月，比较3组的临床疗效，临床症状有所改善，骨密度较治疗前有所提高视为有效，观察治疗前后血钙、血碱性磷酸酶及骨密度的变化。结果：总有效率对照组为73．33％，琥珀丸组为80％，壮骨片组为91．66％，琥珀丸组和壮骨片组总有效率高于对照组，差异具有统计学意义（χ2=6．90，P=0．03）。治疗前各组血钙、ALP、BMD比较，差异均无统计学意义（F=0．053，P=0．954；F=0．236，P=0．790；F=0．345，P=0．709）；治疗后各组血钙、ALP比较，差异均无统计学意义（F=2．912，P=0．057；F=0．771，P=0．464）；治疗后各组BMD比较，差异有统计学意义（F=3．967,P=0．021）。各组治疗前后血钙比较，差异均有统计学意义（P=0．030，P=0．021，P=0．000）。对照组治疗前后ALP比较，差异无统计学意义（P=0．058）；琥珀丸组及壮骨片组治疗前后ALP比较，差异均有统计学意义（P=0．000，P=0．001）。对照组治疗前后BMD比较，差异无统计学意义（P=0．362）；琥珀丸组及壮骨片组治疗前后BMD比较，差异均有统计学意义（P=0．030，P=0．000）。结论：琥珀丸和壮骨片治疗骨质疏松症患者，可明显改善患者的血钙浓度，增加骨密度，改善骨质结构，提高临床治疗效果。Objective： To observe the clinical effects of Hupo Pills and Zhuanggu Tablets in treating osteoporosis. Methods： A total of 180 osteoporosis patients were randomly divided into Hupo Pills group, Zhuanggu Tablets group and the control group. Control group （n = 60） were treated with Caltrate D600. Hupo Pills group （n = 60） and Zhuanggu Tab- lets group（ n = 60） were treated with Caltrate D600 plus Hupo Pills or Zhuanggu Tablets lrespectively. The three groups were treated for 3 consecutive months. The clinical symptoms effective rate was improved and the bone mineral density was increased compared with those before treatment and we observed the clinical efficacy, blood calcium, ALP and BMD. Results ： The total curative effect rates of control group, Hupo Pills group and Zhuanggu Tablets group were 73.33% ,80% and 91.66% ,respectively. And the total curative effect rate of Hupo Pills group and Zhuanggu Tablets group was higher than that of the control group. There was no difference in the level of blood calcium, ALP and BMD before treatment in each group （ F = 0.053, P = 0. 954 ; F = 0. 236, P = 0. 790 ; F = 0.345, P = 0. 709 ）, so was the blood calcium and ALP af- ter treatment in each group （ F = 2.912, P = 0. 057 ; F = 0.77 1, P = 0. 464 ）. But the BMD after treatment in each group had statistical significant （ F = 3. 967, P = 0.021 ）. The level of blood calcium was increased than those in the same group before treatment （P = 0. 030,P = 0.021,P = 0.000）. There was no difference of ALP before and after treatment in control group（P = 0. 058）. But the ALP in Hupo Pills group and Zhuanggu Tablets group were lower than that before treat- ment （ P = 0. 000, P = 0.001 ）. There was no difference of BMD before and after treatment in control group （ P = 0. 362 ）. But the BMD in Hupo Pills group and Zhuanggu Tablets group were higher than that before treatment （ P = 0. 030, P = 0. 000）. Conclusion： Hupo Pills and Zhuanggu Tablets are able to promote the levels of blood calc

关 键 词：临床观察 琥珀丸 壮骨片 血钙 骨密度 血碱性磷酸酶 

分 类 号：R258.8[医药卫生—中医内科学]