白术-白芍药对最佳配伍比例研究  

Optimization Compatibility Proportion of Rhizoma Atractylodis Macrocephalae-Radix Paeoniae Alba

作　　者：孙萍萍[1] 余平[1] 葛淑瑜 楼婷婷[1] 

机构地区：[1]浙江省立同德医院,浙江杭州310012

出　　处：《中华中医药学刊》2016年第11期2718-2721,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省中医药科技计划项目(2015ZA023)

摘　　要：目的:研究白术-白芍不同比例配伍对水提液中有效成分含量的影响,探求药对的最佳配伍比例。方法:运用HPLC切换波长法考察白术、白芍单独水提液与白术-白芍药对不同比例配伍共提液中芍药苷、白术内酯(Ⅰ、Ⅲ)的含量变化情况。结果:与白术、白芍单提液相比,白术-白芍(1∶1,2∶3,1∶2,2∶5,3∶2,2∶1,5∶2)7个比例配伍后芍药苷、白术内酯(Ⅰ、Ⅲ)的含量均有不同程度的提高。结论:白术与白芍配伍后,对彼此有效成分的溶出有一定的促进作用,白术-白芍药对的最佳配伍比例为2∶3。Objective ： To optimize the compatibility proportion of Rhizoma Atractylodis Macrocephalae - Radix Paeoni- ae Alba via determining the content of active constituents in water - extraction solution of different compatibility propor- tion. Method： The high ：performance liquid chromatography with switching wavelength was performed on the content deter- mination of peoniflorin, atractylenolide Ⅰand atractylenolide Ⅲ in single extraction solution and different compatibility proportion extraction solution of Rhizoma Atractylodis Macrocephalae and Radix Paeoniae Alba. Result Compared to sin- gle extraction solution, the contents of peoniflorin, atractylenolide Ⅰ and atractylenolideⅢ in 7 compatibility proportion extraction solution of Rhizoma Atractylodis Macrocephalae - Radix Paeoniae Alba （ 1 ： 1,2 ： 3,1 ： 2,2 ： 5,3 ： 2,2 ： 1,5 ： 2） were increased in various degrees. Conclusion The compatibility use of Rhizoma Atractylodis Macrocephalae - Radix Paeoniae Alba can improve the dissolution of active constituents and the optimization compatibility proportion is 2 ： 3.

关 键 词：白术-白芍药对 配伍比例 芍药苷 白术内酯Ⅰ 白术内酯Ⅲ HPLC 

分 类 号：R284.1[医药卫生—中药学]