和肾络法治疗糖尿病肾病终末期的效果及对各实验指标的影响  

Efficacy of renal collaterals methods in the treatment of diabetic nephropathy of end-stage and its influence on the experimental indexes

作　　者：黄克基 孙云松 刘先英 孙红 

机构地区：[1]山东省青岛市海慈医疗集团肾病科,山东青岛266033

出　　处：《中国医药导报》2016年第30期189-192,共4页China Medical Herald

基　　金：山东省青岛市医疗卫生优秀人才培养计划资助项目(2013ZDZK-106)

摘　　要：目的探讨和肾络法治疗糖尿病肾病终末期的效果及对各实验指标的影响。方法回顾性分析2014年1月~2015年6月山东省青岛市海慈医疗集团81例糖尿病肾病终末期患者资料,根据治疗方法分成治疗组(46例)和对照组(35例)。对照组患者采用西医常规治疗,治疗组在对照组治疗基础上加用和肾络法中药汤剂治疗。4周为1个疗程,3个疗程后评价临床疗效。观察两组患者治疗前后的临床疗效、临床症状积分以及对各实验指标的影响。结果治疗3个月后,治疗组总有效率和显效率均显著高于对照组(P<0.05)。治疗组治疗后的临床症状积分较治疗前明显改善(P<0.05),而对照组治疗前后的症状改善不明显(P>0.05),治疗后治疗组的症状积分显著低于对照组(P<0.05)。与治疗前组内比较,治疗后,治疗组的Scr、BUN水平显著降低,Hb、Alb水平显著提高(P<0.05),而UA水平差异无统计学意义(P>0.05),对照组的Scr水平显著降低(P<0.05);组间比较,治疗后治疗组的Scr显著低于对照组,Hb、Alb水平显著高于对照组(P<0.05),而BUN、UA水平差异无统计学意义(P>0.05)。与治疗前比较,两组患者治疗后TG、LDL-C、HDL-C均明显改善(P<0.05),且治疗后治疗组患者TG、LDL-C、HDL-C改善显著优于对照组(P<0.05)。结论在西医治疗基础上加用和肾络法治疗糖尿病肾病终末期能提高效果,改善患者的肾功能及血脂等指标,改善临床症状,对延缓终末期糖尿病肾病的发展,具有良好作用。Objective To investigate the efficacy of renal collaterals methods in the treatment ot diabetic nephropamy of end-stage and its influence on the experimental indexes. Methods Data of 81 cases of patients with diabetic nephropathy of end-stage treated in Qingdao Haici Medical Group from January 2014 to June 2015 were analyzed retrospectively. According to the treatment method patients were divided into the treatment gorup （46 cases） and the control group （35 cases）. Patients in the control gorup were given conventional Western medicine treatment, patients in the treatment gorup were given renal collaterals method herbal soup on the basis of the control group, 4 weeks as one course of treatment. The clinical effects were evaluated after 3 courses of treatment. The clinical effects, clinical symptom scores before and after treatment and its influence on the experimental indexes were observed. Results After 3- month of treatment, the rates of efficiency and total efficiency in the treatment group were significantly higher than those in the control group （P 〈 0.05）. The clinical symptom scores of treatment group were better than that before treatment （P 〈 0.05）, and there were no differences after and before treatment in the control group （P 〉 0.05）. After treatment, the clinical symptom scores of the treatment group were lower than those of the control group, with statistically significant differences （P 〈 0.05）. Compared with pretherapy, Scr and BUN after treatment were significantly reduced, and Hb, Alb levels increased significantly （P 〈 0.05）, while the UA level had no significant differences （P 〉 0.05） in the treatment group; while the control group of Scr level decreased significantly （P 〈 0.05）. The Scr of the treatment group was significantly lower than the control group, the levels of Hb, Alb in the treatment group were：significantly higher than those in the control group （P 〈 0.05）, while the levels of BUN, UA had no significant differences （P �

关 键 词：糖尿病肾病 终末期 和肾络法 西医 肾功能 临床症状积分 

分 类 号：R587[医药卫生—内分泌]