P53与Mta-1在膀胱癌中的表达及临床意义  

Expressions of P53 and Mta-1 in Bladder Cancer and Their Clinical Significance

作　　者：王哲[1] 刘硕[1] 苗文龙[1] WANG Zhe LIU Shuo MIAO Wen-long(Urology Department, First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei 075000, Chin)

机构地区：[1]河北北方学院附属第一医院泌尿外科,河北张家口075000

出　　处：《河北北方学院学报（自然科学版）》2016年第10期5-8,共4页Journal of Hebei North University:Natural Science Edition

摘　　要：目的探讨P53及Mta-1在膀胱癌中的表达及临床意义。方法采用免疫组化法分别对60例膀胱癌和10例癌旁正常膀胱黏膜的石蜡标本行P53与Mta-1蛋白检测。结果 P53和Mta-1在膀胱癌标本中的阳性率分别是63.3%(38/60)和71.6%(43/60),在正常膀胱黏膜组织中的阳性率均为0%,差异有显著性(P<0.01)。P53和Mta-1阳性表达均与膀胱癌患者的临床分期及病理分级相关(P<0.05);与患者性别、年龄、肿瘤大小等不相关(P>0.05)。Mta-1与P53在膀胱癌的表达呈正相关(r=0.596,P=0.000)。结论P53及Mta-1的高表达可作为膀胱癌恶性程度及判断预后的重要指标。Objective To investigate the expression of P53 and Mta-1in bladder cancer tissue and their clinical significance.Methods The samples comprised of formalin-fixed paraffin-embedded tissue blocks of 60 cases of primary bladder cancer and 10 cases of normal bladder mucosa.The expressions of P53 and Mta-1in the samples were immunohistochemically determined and their correlation with clinicopathological parameters was statistically analyzed.Results The rates of positive expression of P53 and Mta-1in bladder cancer tissue were 63.3%（38/60）and 71.6%（43/60）,respectively,and in normal bladder mucosa0%.There was significant difference between the two groups（P〈0.01）.Furthermore,high expressions of P53 and Mta-1in bladder cancer were closely related with the clinical stage and pathological grade（P〈0.05）,but there was no obvious relationship with patient＇s sex,age and tumor size（P〉0.05）.Also,it was found that the expression of P53 was positively correlated with Mta-1expression in bladder cancer（r=0.596,P=0.000）.Conclusion Expressions of P53 and Mta-1in bladder cancer tissue could serve as significant biomarkers to predict the aggressiveness and prognostic outcome.

关 键 词：膀胱癌 P53 MTA-1 

分 类 号：R737.14[医药卫生—肿瘤]