具有附属器官再生性能的人工皮肤替代物研究进展  

Progress of Skin Substitutes for Regenerating Appendages

作　　者：李陆艳 张兵[1] 李秀媛[1] 马列[1,2] 

机构地区：[1]浙江大学高分子科学与工程学系高分子合成与功能构造教育部重点实验室,浙江省杭州市310027 [2]复旦大学聚合物分子工程国家重点实验室,上海市200000

出　　处：《组织工程与重建外科杂志》2016年第5期313-318,330,共7页Journal of Tissue Engineering and Reconstructive Surgery

基　　金：国家重点基础研究发展计划(973)项目(2011CB606203);国家自然科学基金项目(51322302)

摘　　要：缺损皮肤的再生与修复一直是临床亟待解决的难题之一。目前,虽然已有众多的皮肤替代物实现了临床应用,但是多数只能简单地实现表皮层和真皮层的结构性修复,修复的皮肤组织往往不含毛囊、汗腺、皮脂腺等皮肤附属器,难以重建皮肤的各项功能。本文从种子细胞、支架材料及其生物活性化三个方面,详细介绍了具有附属器官再生功能,特别是毛囊再生性能的皮肤替代物的研究进展,同时对该领域未来发展进行展望。[Summary] It is still an urgent problem to regenerate and repair skin defects in clinic. Up to now, even though a lot of skin substitutes have been developed and realize the clinical application, most of them can only repair the structure of epidermis and simple dermis. The reconstructive skin tissue can＇t reconstruct the functions of normal skin, usually due to the lack of skin appendages, such as hair follicles, sweat glands and sebaceous glands. In this paper, from the aspects of seed cells, scaffold materials and its bioactivation, the skin substitutes with the ability of regenerating skin appendages, especially hair follicles were reviewed. Finally, some important challenges for the future studies in this field were discussed.

关 键 词：毛囊 汗腺 皮脂腺 皮肤替代物 生物材料 

分 类 号：Q813.12[生物学—生物工程]