甲巯咪唑和丙硫氧嘧啶治疗甲亢的临床疗效对比分析  

Comparative analysis of clinical efficacy of methimazole and propylthiouracil in the treatment of hyperthyroidism

作　　者：陈敏[1] 谢乃强[1] 伍华[1] 

机构地区：[1]肇庆市第一人民医院,肇庆526000

出　　处：《北方药学》2016年第11期6-7,共2页Journal of North Pharmacy

摘　　要：目的：评价甲巯咪唑和丙硫氧嘧啶治疗甲亢的临床疗效、安全性，总结治疗经验。方法：以2014年1月～2016年1月，医院门诊收治的甲亢患者作为研究对象，共入选对象100例，根据入院顺序，随机对照分组，甲巯咪唑组、丙硫氧嘧啶组各入选对象50例，分别给予组名相同药物治疗，标准方案，用药6个月，评价疗效，统计对比不良反应发生情况。结果：甲巯咪唑组退出2例，丙硫氧嘧啶组退出2例；甲巯咪唑组、丙硫氧嘧啶组第1、2、3、6个月后，甲状腺功能恢复率分别为46．0％、60．0％、66．0％、70．0％，44．0％、50．0％、64．0％、60．0％，差异无统计学意义（P〉0．05）；6个月后，甲巯咪唑组、丙硫氧嘧啶组甲状腺功能FT3、FT4、TSH水平差异无统计学意义（P〉0．05）；甲巯咪唑组肝损伤发生率、不良反应合计例次率低于丙硫氧嘧啶组，差异均有统计学意义（P〈0．05）。结论：甲巯咪唑和丙硫氧嘧啶治疗甲亢对甲状腺功能恢复效果无明显差异，但前者不良反应发生率更低。Objective： Test evaluation of thiamazole and propylthiouracil treatment of hyperthyroidism clinical curative effect, safety, summed up the experience in the treatment. Methods：In January 2014 to 2016 January, hyperthyroidism patients in the outpatient department of our hospital as the research object, a total of selected objects in 100 cases, according to the order of admission were randomly divided into two groups, thiamazole and propyhhiouracil group all selected objects 50 cases, were treated group were treated with the same drug, standard solutions, 6 months of treatment, curative effect evaluation, statistical comparison of adverse reactions. Results： Thiamazole group exit in 2 cases and propyhhiouracil group exit in 2 cases; a sparse imidazole group, propylene propyhhiouracil group 1, 2, 3, 6 months later, thyroid function recovery rate was 46.0%, 60.0% and 66.0%, 70.0%, 44.0%, 50.0%, 64,0%, 60.0%, the difference was not statistically significant （P〉0.05）; After 6 months, a sparse imidazole group, propyhhiouracil group, the thyroid function of FT3, FT4 and TSH levels were no statistical significance （P〉0.05）; A sparse imidazole groups of liver injury rate, adverse reactions together with a rate lower than the MTU group, the differences were statistically significant （P〈0.05）. Conclusion：Thiamazole and propylthiouraeil treatment of hyperthyroidism on thyroid function recovery effect had no significant difference, but the former adverse reactions occur at a lower rate.

关 键 词：甲状腺功能亢进 甲巯咪唑 丙硫氧嘧啶 

分 类 号：R581.1[医药卫生—内分泌]