非对称取代脲的合成与应用  

Synthesis and Application of Unsymmetrically Substituted Ureas

作　　者：薛燕[1] 吴思忠[1] 彭爱东[1] 杨瑛[1] 陆世维[1] 

机构地区：[1]中国科学院大连化学物理研究所国家催化工程技术研究中心,大连116023

出　　处：《有机化学》2002年第8期529-535,共7页Chinese Journal of Organic Chemistry

摘　　要：总结了合成非对称取代脲的几种方法 ,分析了各种方法的利弊 ,介绍了非对称取代脲的主要应用 .指出直接利用一氧化碳进行硒催化的胺与硝基化合物的氧化还原羰基化反应来合成非对称取代脲的方法是比较有发展前景的方法 。Unsymmetrically substituted ureas are widely used in agriculture, medicine and biology. Their main synthetic methods are summarized and analyzed in this article. According to their advantages and disadvantages, it is pointed out that the catalytic method of directly using carbon monoxide is more promising and efficient for the synthesis of unsymmetrical ureas. Combined with our own research work, the substituted reaction of ureas and amines, as well as selenium-catalyzed oxidative carbonylation of amines and reductive carbonylation of nitro compounds with carbon monoxide as a carbonyl reagent are recommended in detail. Through one-step or two-step, unsymmetrical ureas can be obtained easily and conveniently.

关 键 词：非对称取代脲 合成 应用 硒催化 还原羰基化 置换反应 光气法 叠氮化合物法 一氧化碳 

分 类 号：O626[理学—有机化学]