乌司他丁对缺血性脑血管病介入治疗患者血清S100B质量浓度及术后认知功能的影响  

The effects of ulinastatin on the concentration of S100B and postoperative cognitive function to patients with ischemic cerebrovascular disease undergo interventional therapy

作　　者：刘中光 姚百洋 马玉恒[2] 张树峰[2] 李永旺[2] 

机构地区：[1]济宁医学院附属医院,山东济宁272000 [2]中国人民解放军火箭军总医院,北京100088

出　　处：《暨南大学学报（自然科学与医学版）》2016年第5期407-410,共4页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：北京市自然科学基金项目(7142169)

摘　　要：目的:研究乌司他丁对缺血性脑血管病介入治疗患者血清S100B质量浓度及认知功能的影响,探讨乌司他丁对脑缺血患者的脑保护作用.方法:本研究为随机对照临床研究,选择拟在全麻下行介入治疗的缺血性脑血管病患者60例,性别不限,年龄40~65岁,BMI 20~30 kg/m^2,将其随机分为两组(n=30):乌司他丁组(U组)和对照组(C组).U组患者麻醉诱导前30 min给予乌司他丁10 000 U/kg(由生理盐水稀释至100 m L静脉滴注),C组患者在相同时间段静脉滴注100 m L生理盐水.于手术前及术后第1、3天行外周静脉采血,采用ELISA检测患者血清S100B质量浓度;同时在两组患者手术前及术后第1、3天,用MMSE评价其认知功能.结果:术后第1天和第3天,U组患者血清S100B质量浓度显著低于C组(P<0.05);同时,术后第1天,U组患者MMSE评分高于C组(P<0.05).结论:乌司他丁预处理可降低缺血性脑血管病介入治疗患者血清S100B质量浓度并改善患者术后早期认知功能,具有一定的脑保护作用.Aim：To research the effects of ulinastatin on the concentration of S1 00B and the score of cognitive function to the patients with ischemic cerebrovascular disease undergone interventional therapy, and to explore the cerebral protection effects of ulinastatin.Methods：This study is a randomized controlled clinical study.A total of interventional therapy in 60 cases with an ischemic cerebrovascular disease,all genders,40 -65 years old,BMI 20 -30,were randomly divided into 2 groups （n =30 each）：Group U （the control group）was given Ulinastation 1 0 000 U /kg （diluted to 1 00 mL by normal saline） before 30 minutes of anesthesia induction;groups C was given 1 00 mL of normal saline on the same times.Blood through peripheral venous before surgery and on the first and third days after operation,and to detect concentration of S1 00B in serum of this patients using Enzyme -linked immunosorbant assay. To evaluate the cognitive function of these patients with the simple Mental State examination scale at the same time.Results：The concentration of S1 00B in group U was lower than group C on the first and third days after operation;the MMSE scale of group U was higher than group C on the third day after operation.Conclusion：Ulinastatin has powerful cerebral protection effects,pretreatment of ulinastation 1 0 000 U /kg before 30 minutes of anesthesia induction could reduce the concentration of S1 00B in serum and improve early postoperative cognitive dysfunction in patients with ischemic cerebrovascular disease undergo an interventional therapy.

关 键 词：乌司他丁 S1 00B 蛋白 缺血性脑血管病 术后认知功能障碍 

分 类 号：R614.21[医药卫生—麻醉学]