病毒性脑炎患儿血清和脑脊液中Gal-9的变化  

Gal-9 changes in serum and cerebrospinal fluid in children with viral encephalitis

作　　者：王学禹[1] 王文娟[2] 张秀芳[2] 

机构地区：[1]山东大学附属省立医院,山东济南250021 [2]山东省千佛山医院,山东济南250014

出　　处：《临床儿科杂志》2016年第11期811-814,共4页Journal of Clinical Pediatrics

摘　　要：目的探讨病毒性脑炎(VE)患儿血清和脑脊液中半乳糖凝集素-9(Gal-9)的变化,及其对疾病的诊断、判断预后的指导意义。方法采用双抗体夹心酶联免疫吸附法检测VE患儿急性期、恢复期以及对照组血清和脑脊液中Gal-9的水平,并进行比较。结果 VE患儿急性期、恢复期以及对照组患儿进行比较,三组的血清和脑脊液中Gal-9水平的差异均有统计学意义(F=92.60、81.90,P<0.01)。其中,VE患儿急性期、恢复期的血清和脑脊液中Gal-9水平均高于对照组,差异有统计学意义(P<0.01);VE恢复期的血清和脑脊液中Gal-9水平均高于急性期,差异有统计学意义(P<0.01)。VE和对照组全体患儿血清中Gal-9水平与脑脊液中Gal-9水平呈正相关(r=0.523,P<0.01)。VE患儿脑脊液中Gal-9水平与有核细胞数呈负相关(rs=-0.469,P<0.001)。结论 Gal-9可能参与VE的发病过程。Objective To investigate the changes of Galectin-9 （Gal-9） in serum and cerebrospinal fluid in children with viral encephalitis （VE） and to epxplore its potential signiifcance in the diagnosis and prognosis of VE.Methods The levels of Gal-9 in serum and cerebrospinal lfuid were detected by enzyme-linked immunosorbent assay double-antibody sandwich and compared in 30children with VE in acute and convalescent phases and in 12 children without VE.Results The differences of Gal-9 levels in serum and cerebrospinal lfuid were statistically signiifcant between VE acute phase group and VE recovery phase group as well as control group （F= 92.70, 81.95, P〈0.01）. The Gal-9 levels in serum and cerebrospinal lfuid of the children in VE acute phase and of the children in VE recovery phase were signiifcantly higher compared to those in the control group （P〈0.01）. The levels of Gal-9 in serum and cerebrospinal lfuid of children in VE convalescent phase are signiifcantly higher than those in acute phase of VE （P〈0.01）. There was a positive correlation between levels of Gal-9 in cerebrospinal lfuid and in serum （r=0.523,P〈0.01）. The levels of SP-D correlated negatively with the total CSF leucocytic count in children of VE （rs=-0.469,P〈0.001）.Conclusions Gal-9 played an important role in the later stage of viral encephalitis recovery.

关 键 词：病毒性脑炎 乳糖凝集素-9 血清 脑脊液 儿童 

分 类 号：R725.1[医药卫生—儿科]