胸腔积液结核感染T细胞斑点试验诊断结核性胸膜炎的Meta分析  

The value of T-SPOT. TB of pleural effusion in diagnosis of tuberculous pleurisy： a meta-analysis

作　　者：许利芳[1] 胡克[1] 

机构地区：[1]武汉大学人民医院呼吸内科,430060

出　　处：《临床内科杂志》2016年第10期675-678,共4页Journal of Clinical Internal Medicine

摘　　要：目的系统评价胸腔积液结核感染T细胞斑点试验（T-SPOT．TB）在结核性胸膜炎中的诊断价值。方法检索中国知网、万方、维普、Pubmed、Elsevier等数据库，收集建库至2015年11月以胸腔积液T-SPOT．TB诊断结核性胸膜炎的相关文献，提取四格表等信息，采用Meta-Discl．4软件进行分析。结果共纳入21篇文献，结核性胸膜炎组1229例，对照组714例。诊断价值结果如下：汇总灵敏度为0．93（95％C10．92-0．95）；汇总特异度为0．88（95％C10．86-0．91），汇总阳性似然比为7．16（95％CI4．72-10．85）；汇总阴性似然比为0．09（95％C10．07-0．12）；诊断比值比97．49（95％C153．66-177．13）；受试者工作特征曲线（SROC）曲线下面积为0．9624，Q值为0．9080。结论胸腔积液结核感染T细胞斑点试验对诊断结核性胸膜炎有较高的诊断价值。Objective To assess the diagnosis value of tuberculosis infection-T cells enzyme- linked immunospot assay （T-SPOT. TB ） of pleural effusion for tuberculous pleurisy. Methods By searching CNKI, Wanfang, Cqvip, PubMed and Elsevier, the clinical trials of T-SPOT. TB of pleural effusion in the diagnosis of tuberculous pleurisy from the time of database establishment to November 2015 were included in the meta-analysis, then extract the information of four-fold table. The statistical analysis was made by Meta-Disc 1.4 software. Results 21 articles were recruited in the study with 1 229 cases in the patients groups and 714 cases in the control groups. The outcomes of the diagnostic value were as follows ： summary sensitivity was 0.93 （95 % CI0. 924）. 95 ）, summary specificity was 0.88 （ 95 % CI 0. 86- 0.91 ）, positive likelihood ratio was 7.16 （ 95 % CI 4.72-10.85 ）, negative likelihood ratio was 0.09 （ 95 % CI 0. 07 4）. 12 ）, diagnostic odds ratio （DOR） was 97.49 （95 % C153. 66-177.13 ）, AUCSROC was 0. 9624 and Q value was 0. 9080. Conclusion T-SPOT. TB has a high diagnostic efficiency of tuberculous pleuri-

关 键 词：结核性胸膜炎 结核感染T细胞斑点试验 诊断 META分析 

分 类 号：R521.7[医药卫生—内科学]