Cyclometallated iridium phosphors with amino acid ancillary ligand for intracellular imaging  

作　　者：Tian-Yi Li Hua-Chao Chen Yi-Ming Jing Hua-Bo Han Xiao Liang You-Xuan Zheng Wei-jiang He 

机构地区：[1]State Key Laboratory of Coordination Chemistry,Collaborative Innovation Center of Advanced Microstructures,School of Chemistry and Chemical Engineering,Nanjing University

出　　处：《Chinese Chemical Letters》2016年第10期1582-1585,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.21371093);the Natural Science Foundation of Jiangsu Province(No.BK20130054)

摘　　要：Two new iridium complexes, （dfppy）2Ir（L-alanine） （dfppy-2-（2,4-difluorophenyl）pyridine） and （piq）21r（L-alanine） （piq - 1-phenylisoquinoline） were prepared with L-alanine as ancillary ligand. The two complexes show bright greenish-blue and red emission respectively. Theoretic study demonstrated that the emission nature of these complexes is mainly determined by the main ligand. And their improved aqueous solubility and the retained quantum yield favor their application in cell imaging. Intracellular imaging suggested that these two complexes have fine cell membrane permeability and is mainly distributed in cytoplasm. This study displayed a new strategy to design aqueous soluble phosphorescent cyclometallated if（Ⅲ） complex via introducing amino acid as ancillary ligand.Two new iridium complexes, （dfppy）2Ir（L-alanine） （dfppy-2-（2,4-difluorophenyl）pyridine） and （piq）21r（L-alanine） （piq - 1-phenylisoquinoline） were prepared with L-alanine as ancillary ligand. The two complexes show bright greenish-blue and red emission respectively. Theoretic study demonstrated that the emission nature of these complexes is mainly determined by the main ligand. And their improved aqueous solubility and the retained quantum yield favor their application in cell imaging. Intracellular imaging suggested that these two complexes have fine cell membrane permeability and is mainly distributed in cytoplasm. This study displayed a new strategy to design aqueous soluble phosphorescent cyclometallated if（Ⅲ） complex via introducing amino acid as ancillary ligand.

关 键 词：Iridium complexL-AlanineWater solubilityPhosphorescent materialsCell imaging 

分 类 号：O641.4[理学—物理化学]