An efficient etherification of Ginkgol biloba extracts with fewer side effects in a micro-flow system  

作　　者：Yin-Lin Qin Wei He Mei Su Zheng Fang Ping-Kai Ouyang Kai Guo 

机构地区：[1]College of Biotechnology and Pharmaceutical Engineering,Nanjing Technology University,Nanjing 210009,China [2]Jiangsu Carephar Pharmaceutical Co.,Ltd.,Nanjing 210014,China [3]School of Pharmaceutical,Nanjing Technology University,Nanjing 210009,China [4]State Key Laboratory of Materials--Oriented Chemical Engineering Nanjing Technology University,Nanjing 211816,China

出　　处：《Chinese Chemical Letters》2016年第10期1644-1648,共5页中国化学快报（英文版）

基　　金：financially supported by the National Key Basic Research Program of China(973 Program,Nos.2012CB725204 and 2012CB721104);the National Natural Science Foundation of China(Nos.U1463201,81302632,21522604 and21402240);the youth in Jiangsu Province Natural Science Fund(No.BK20130913);National Science and Technology Major Projects for"Major New Drugs Innovation and Development"(No.2013ZX09103001-004)

摘　　要：In this study, etherification of ginkgolide B and dimethylaminoethyl chloride hydrochloride was investigated as a model reaction in a micro-flow system （MFS）, providing the resulting ethers in high yield with fewer side effects. Meanwhile, this novel process in MFS worked well for other ginkgolides from Ginkgol biloba and halides, giving moderate yields.In this study, etherification of ginkgolide B and dimethylaminoethyl chloride hydrochloride was investigated as a model reaction in a micro-flow system （MFS）, providing the resulting ethers in high yield with fewer side effects. Meanwhile, this novel process in MFS worked well for other ginkgolides from Ginkgol biloba and halides, giving moderate yields.

关 键 词：EtheriflcationGinkgolide BMicro-flow systemFew side effects 

分 类 号：O621.25[理学—有机化学]