伊曲康唑联合硝酸咪康唑治疗复发性假丝酵母菌阴道炎疗效观察  

The efficacy of itraconazole and miconazole nitrate for recurrent monilial vaginitis

作　　者：谢旭敏[1] 兰苏平[1] 谢妙妙 Xie Xumin Lan Suping Xie Miaomiao(Department of Ccynaecology and Obsterics, Lishui hospital of traditional Chinese medicine, Lishui, Zhejiang 323000, China （ Xie XM , Lan SP Department of Gynaecology and Obsterics , Lishui city women ＂s Hospital, Lishui, Zhejiang 323000, China（ Xie MM)

机构地区：[1]丽水市中医院妇产科,浙江省丽水323000 [2]丽水市妇幼保健院围产期保健科,浙江省丽水323000

出　　处：《中国基层医药》2016年第21期3263-3266,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：研究伊曲康唑联合硝酸咪康唑治疗复发性假丝酵母菌阴道炎（RVVC）的疗效。方法选取2015年3月至2016年3月收治的已确诊的 RVVC 患者200例，按照随机数字表法分为研究组和对照组，每组各100例。对照组采用硝酸咪康唑阴道软胶囊，阴道给药，洗净后将栓剂置于阴道深处，每晚1次，每次1枚，1周为1个疗程。研究组在对照组治疗的基础上加服伊曲康唑胶囊，每天200 mg，口服。用药8周后，对两组进行复查，分析患者临床疗效以及不良反应发生情况。结果研究组治疗总有效率为98％，对照组治疗总有效率为73％，差异有统计学意义（χ2＝25．21，P ＜0．01）。研究组不良反应发生率为13％，对照组不良反应发生率为14％，差异无统计学意义（χ2＝0．04，P ＞0．05）。结论伊曲康唑联合硝酸咪康唑治疗RVVC 的疗效优于单用硝酸咪康唑，不良反应少，使用方便，值得临床推广应用。Objective To study the treatment effect of joint nitric acid imidazole and itraconazole on recurrent candida vaginitis.Methods 200 confirmed cases of patients with recurrent candida vaginitis in our hospital during October 2014 to June 2015 were selected and divided into research group and the control group with random indicator method,with 100 cases in each group.The control group were treated by nitric acid imidazole vaginal soft capsule,with vaginal drug delivery,which shoud put suppository in vaginal depths after washing,for one times a night and one soft capsule every time,and a week was a period of treatment.The patients in the research group received basis treatment of the control group adding itraconazole capsules（200mg per day,oral）.8 weeks after treatment,the patients in this process were reviewed to analyzed clinical efficacy and adverse reactions occured.Results The total effective rate of the research group was 98%,which of the control group was 73%,the difference was statistically significant（χ2 =25.21,P 〈0.01）.The incidence of adverse of patients in the research group was 13%,which of the control group was 14%,there was no statistically significant difference （χ2 =0.04,P 〉0.05 ）.Conclusion The curative effect of itraconazole joint miconazole nitratet to recurrent monilial vaginitis is superior to the use of miconazole nitrate alone, with less adverse reaction,and is easy to use.It is worth clinical application.

关 键 词：念珠菌病 阴道炎 伊曲康唑 硝酸咪康唑 

分 类 号：R711.31[医药卫生—妇产科学]