Crystal Structures of Arabidopsis thaliana Oxalyl- CoA Synthetase Essential for Oxalate Degradation  

作　　者：Minrui Fan Yang Xiao Mei Li Wenrui Chang 

机构地区：[1]National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15th Datun Road, Chaoyang District, Beijing 100101, People's Republic of China [2]University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing, 100049, People's Republic of China [3]These authors contributed equally to this article.

出　　处：《Molecular Plant》2016年第9期1349-1352,共4页分子植物（英文版）

摘　　要：Dear Editor Oxalic acid, the simplest of all dicarboxylic acids, is widely found in all plant species （FranceschJ and Nakata, 2005）. Two pathways exist for oxalate degradation in plants： degradation via oxalate oxidase and ATP- and CoA-dependent decarboxylation of oxalate through a poorly studied series of enzymatic reactions （Giovanelli and Tobin, 1961）. OxalyI-CoA synthetase, the enzyme that initiates the second degradation pathway was recently identified in Arabidopsis thaliana as a protein encoded by ACYL-ACTIVATING ENZYME3 （AAE3）. It was shown that AAE3- dependent degradation of oxalate is important for normal seed development and for defense against oxalate-producing fungal pathogens in Arabidopsis （Foster et al., 2012）. In addition, it was shown recently that AAE3 also plays a role in seed development in maize and rice （Wang et al., 2011）.Dear Editor Oxalic acid, the simplest of all dicarboxylic acids, is widely found in all plant species （FranceschJ and Nakata, 2005）. Two pathways exist for oxalate degradation in plants： degradation via oxalate oxidase and ATP- and CoA-dependent decarboxylation of oxalate through a poorly studied series of enzymatic reactions （Giovanelli and Tobin, 1961）. OxalyI-CoA synthetase, the enzyme that initiates the second degradation pathway was recently identified in Arabidopsis thaliana as a protein encoded by ACYL-ACTIVATING ENZYME3 （AAE3）. It was shown that AAE3- dependent degradation of oxalate is important for normal seed development and for defense against oxalate-producing fungal pathogens in Arabidopsis （Foster et al., 2012）. In addition, it was shown recently that AAE3 also plays a role in seed development in maize and rice （Wang et al., 2011）.

分 类 号：Q94[生物学—植物学]