神安方对改善维持性血液透析患者睡眠障碍的临床疗效观察  

Clinical observation of Chinese herbal medicine on improving sleep disorders in patients with maintenance hemodialysis

作　　者：石国娟[1] 梁真[1] 马金荣[1] 赵丽[1] 李娟[1] SHIGuo-juan LIANGZhen MAJin-rong ZHAOLi LIJuan.(Departmentof nephropathy, Cangzhou integrated traditional Chinese and Western medicine hospital, Cangzhou 061001, China)

机构地区：[1]河北医科大学附属沧州中西医结合医院肾病科,沧州061001

出　　处：《临床肾脏病杂志》2016年第9期526-529,共4页Journal Of Clinical Nephrology

摘　　要：目的睡眠障碍是困扰尿毒症维持性血液透析患者生活质量的一个严重的公共卫生问题。随着医疗技术的进步以及患者生存时间的延长,睡眠障碍作为独立评价预测尿毒症维持血性血液透析患者生活质量和高病死率的指标日益受到重视。本文探讨自拟神安方对改善心脾两虚兼夹痰热型维持性血液透析患者睡眠障碍的临床疗效。方法选择2009年7月至2013年12月在我院行规律维持性血液透析伴有睡眠障碍的患者60例,其中医症候诊断均为心脾两虚兼夹痰热型。采用简单随机抽样的方法将其分成2组,神安方组30例(观察组)和舒乐安定组30例(对照组),实验时间3个月。观察组给予中药配方颗粒1袋每天一次早晚冲服,对照组给予舒乐安定1 mg,每晚睡前口服。应用匹兹堡睡眠质量指数(Pittsburg Sleep Quality Index,PSQI)量表作为评定睡眠质量的指标。2组患者各进行治疗前、后自身比较及2组间比较。结果观察组及对照组治疗前、后PSQI总分均有统计学差异。2组间治疗后PSQI总分比较无统计学差异。观察组11例患者显效,15例好转,4例无效,有效率86.67%。对照组10例患者显效,17例好转,3例无效,有效率90.0%,2组有效率无统计学差异。对照组患者出现嗜睡、精神依赖性、步履蹒跚、共济失调等不良反应,观察组无上述不良反应。结论神安方对改善心脾两虚兼夹痰热型维持性血液透析患者的睡眠障碍疗效可靠、安全,值得推广。Objective Sleep disorder is one of the serious problems in the current health of maintenance hemodialysis patients. Along with the progress of medical technology, the prolongation of the survival time of patients, the severity of sleep disorders as an independent evaluation of the role of the quality of life and high mortality in patients with maintenance hemodialysis has been paid more and more attention. To investigate the clinical effect of traditional Chinese medicine on improving sleep disorders in maintenance hemodialysis patients. Methods 60 cases of hemodialysis patients with sleep disorders were selected. A simple random sampling was used to divide it into two groups, 30 cases of Chinese medicine group（experimental group） and diazepam group（control group） 30 cases, the time of 3 months. The experimental group received 1 bags of Chinese medicine 2 times a day sooner or later each, the control group was given estazolam 1 mg orally at bedtime. The Pittsburgh sleep quality index（Sleep Quality Index Pittsburg, PSQI） was used as the quantitative indicators of sleep, and the two groups were compared before and after treatment, and the two groups were compared between the two groups. Results The traditional Chinese medicine group and estazolam group before and after treatment PSQI scores were statistically significant （P〈0. 05）. Between the two groups after treatment, the total score of PSQI was not statistically significant （P〉0. 05）. In the traditional Chinese medicine group, 11 cases were markedly improved, 15 cases improved, 4 cases had no improvement, and the efficiency was 86. 67%. Estazolam group 10 patients were cured, 17 cases improved and 3 cases without consciousness improved, the effective rate was 90. 0%. Two groups have no difference in statistical efficiency. But compared with estazolam group of sleepiness, mental dependence, staggering gait, ataxia and other side effects, the TCM group without the side effects. Conclusions The traditional Chinese medicine is reliable, safe

关 键 词：终末期肾病 睡眠障碍 中药 

分 类 号：R285.6[医药卫生—中药学]