α-磷酸三钙骨移植材料在骨科领域应用的研究与进展  

Alpha-tricalcium phosphate as a bone graft: research and development in orthopedics

作　　者：肖渝[1] 李彦林[1] 高寰宇 王国梁[1] 夏萍[2] 

机构地区：[1]昆明医科大学第一附属医院运动医学科,云南省昆明市650032 [2]昆明医科大学第一附属医院

出　　处：《中国组织工程研究》2016年第43期6494-6500,共7页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(81460340);云南省骨关节疾病诊疗省创新团队项目(2004HC1018);医疗卫生内设机构研究项目~~

摘　　要：背景:α-磷酸三钙是目前骨移植替代材料当中研究和应用较为广泛的重要骨组织工程材料之一。目的:介绍目前α-磷酸三钙骨移植替代材料的最新研究进展,并展望其在未来发展。方法:由第一作者检索1960年1月至2015年8月Pub Med数据库、FMJS数据库、中国知网数据库、万方数据库、中国生物医学文献数据库,有关使用α-磷酸三钙作为骨移植替代材料的相关文献,英文检索词为"Alpha tricalcium phosphate,Composite material,Bone graft,Bone substitution material",中文检索词为"α-磷酸三钙,复合材料,骨移植,骨替代材料",根据纳入标准排除重复性研究,保留42篇密切相关文献进行归纳总结。结果与结论:α-磷酸三钙是钙磷化合物中研究较多、应用较广的一种,虽然具有良好的生物活性、生物相容性、生物降解性和骨引导能力,但并不具备骨诱导形成能力。因此,将α-磷酸三钙与无机物或有机物结合,形成混合性材料,不仅可克服α-磷酸三钙自身的物理化学特性缺陷,还能增加其弹性,有助于细胞攀附,缩短成骨改建时间,甚至作为载体携带抗菌药物等,这些改进都显著缩减了骨折损伤的修复时间,为未来骨移植材料发展方向提供思路。BACKGROUND： As one of the important bone substitute materials in bone tissue engineering, α-tricalcium phosphate （α-TCP） has been widely applied and researched. OBJECTIVE： To introduce the newest research progress about α-TCP as a kind of bone substitute material, and to prospect its development. METHODS： The first author searched the relative literatures addressing α-TCP as a bone substitute material pubtished from January 1965 to August 2015 in PubMed, FMJS, CNKI, Wanfang and CBM databases. The keywords were ＂alpha tricaicium phosphate, composite material, bone graft, bone substitution material＂ in English and Chinese, respectively. According to the inclusion and exclusion criteria, finally 42 articles were reviewed. RESULTS AND CONCLUSION： α-TCP is one of calcium phosphate compounds which has been extensively applied and researched. It holds good bioactivity, biocompatibility, biodegradability, biodegradation and osteoconductivity except osteoinduction. Therefore, combining α-TCP with inorganic or organic factors to establish the composite material cannot only overcome the shortage of α-TCP in physicochemical characteristics, but also provide a mixed material with better resilience that is easy for cells to adhere, shorten bone reconstruction time, and even can carry antibacterial drugs. All these improvements will markedly shorten the bone repair time and provide a new idea for future development of bone graft materials.

关 键 词：生物相容性材料 磷酸三钙 支架(骨科) 组织工程 生物材料 骨生物材料 骨移植 Α-磷酸三钙 复合材料 骨替代材料 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]