口腔科氢氧化钙制剂的临床应用评价  

Application of calcium hydroxide preparation in the dental field

作　　者：聂二民[1] 姜瑞[1] 张春元[1] 曾尽娣 谈济州 黄喆逊 

机构地区：[1]中山大学附属第一医院口腔科,广东省广州市510080 [2]广州医科大学第一医院口腔科,广东省广州市510120

出　　处：《中国组织工程研究》2016年第43期6514-6520,共7页Chinese Journal of Tissue Engineering Research

基　　金：广东省科技厅社会发展项目(2011B080701086;2011B080701010;2012B061700066)~~

摘　　要：背景:氢氧化钙在临床口腔科应用较为广泛,随着材料科学的发展,其临床应用、物理学性能及生物安全性也越来越优越。目的:总结氢氧化钙材料的物理性能、生物安全性及临床应用现状。方法:以"Calciumhydroxide,Calciumhydroxidepreparation"为英文检索词,以"氢氧化钙,氢氧化钙制剂"为中文检索词,应用计算机检索PubM ed数据库和中国知识网数据库中2010年1月到2016年1月发表的相关文章。结果与结论:氢氧化钙制剂,根据组成分可为单组分和双组分,根据固化形式可分化学固化和光固化,根据性状不同可分为粉剂型和糊剂型。氢氧化钙制剂具有良好的理化性质,可用于口腔根管封药、根管充填、直接盖髓、间接盖髓、活髓切断术及根尖诱导等,临床评价和实验研究认为氢氧化钙制剂具有较好的生物安全性且临床应用效果较好,但在其实验室研究和临床应用的探索过程中,还有许多亟待解决和深入探究的问题。BACKGROUND： Calcium hydroxide has been used widely in clinical dental field, and its physical properties and bio-safety become more excellent along with the development of material science. OBJECTIVE： To summarize the physical properties, bio-safety and clinical application of calcium hydroxide materials. METHODS： A computer-based online research was performed in PubMed and CNKI databases using the keywords of＂calcium hydroxide, calcium hydroxide preparation＂ in English and in Chinese, respectively, to retrieve relevant articles published from January 2010 to January 2016. RESULTS AND CONCLUSION： Calcium hydroxide preparation can be respectively divided into mono-component and bio-component, chemical curing and light curing, as well as power form and paste form according to its components, curing form and characteristics. Calcium hydroxide preparation has good physicochemical properties that can be used for dental root canal, root canal filling, direct pulp capping, indirect pulp capping, vital pulpotomy, and apexification. Clinical evaluation and experimental research have confirmed that the calcium hydroxide preparation has good biological safety and clinical effects; however, some urgent problems still need to be studied in depth.

关 键 词：牙髓复盖术 根尖诱导形成术 综述 组织工程 生物材料 口腔生物材料 氢氧化钙 氢氧化钙制剂 临床应用 物理性能 生物安全性 

分 类 号：R318[医药卫生—生物医学工程]