Efficient Synthesis of Isoquinolines by AgNO3-Catalyzed Sequential Imination-Annulation of 2-Alkynyl Aldehydes with Ammonium Bicarbonate  

作　　者：Yunhui Zhao Mingjian Luo Yubo Li Xiong Liu Zilong Tang Keqin Deng Gang Zhao 

机构地区：[1]Hunan Province College Key Laboratory of QSAR/QSPR, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201, China [2]Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China [3]Key Laboratory of Theoretical Chemistry and Molecular Simulation, Ministry of Education, Xiangtan, Hunan 411201, China

出　　处：《Chinese Journal of Chemistry》2016年第9期857-860,共4页中国化学（英文版）

基　　金：The generous financial support from the National Natural Science Foundation of China （Nos. 21372070 and 21471052） and the Hunan Provincial Education Department Scientific Research Fund （No. 14k035） are gratefully acknowledged.

摘　　要：An operationally simple approach for the tandem synthesis of isoquinolines by the reaction of o-alkynylalde- hydes with ammonium bicarbonate via Ag-catalyzed 6-endo-dig ring closure is described. The reaction conditions and the scope of the reaction are examined, and a variety of substituted isoquinolines are prepared in moderate to excellent yields.An operationally simple approach for the tandem synthesis of isoquinolines by the reaction of o-alkynylalde- hydes with ammonium bicarbonate via Ag-catalyzed 6-endo-dig ring closure is described. The reaction conditions and the scope of the reaction are examined, and a variety of substituted isoquinolines are prepared in moderate to excellent yields.

关 键 词：ISOQUINOLINES ANNULATION imination silver nitrate o-alkynyl aldehydes 

分 类 号：O[理学]