养阴益气合剂对口腔扁平苔藓患者血清及唾液干扰素γ和白细胞介素10水平的影响及临床意义  

Clinical significance and influence of Yangyin Yiqi mixture on levels of interferon -γand interleukine -10 in serum and saliva of oral lichen planus patients

作　　者：周淑珍[1] 高云云[2] 谢静[2] 高盂飞 

机构地区：[1]慈溪市人民医院口腔科,浙江省慈溪315300 [2]温州医科大学附属第一医院口腔科,浙江省温州325000

出　　处：《中国基层医药》2016年第22期3366-3369,共4页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省温州市科技局项目（Y20130260）

摘　　要：目的：评价养阴益气合剂联合西药治疗口腔扁平苔藓的临床疗效及对患者血清及唾液干扰素γ（IFN-γ）、白细胞介素10（IL-10）表达水平的影响。方法将60例口腔扁平苔藓（OLP）患者按照随机分组法分为对照组和观察组，每组30例。对照组病损基底部注射曲安奈德和利多卡因；观察组在对照组治疗方法的基础上，口服养阴益气合剂。两组患者均治疗2个月。比较两组临床疗效、客观指标评分、血清及唾液IFN-γ、IL-10表达水平、不良反应。结果观察组总有效率（86．67％）显著高于对照组（63．33％）（χ2＝11．64，P ＜0．01）；两组客观指标评分均显著低于治疗前（t ＝8．52、12．51，均 P ＜0．01），且观察组显著低于对照组（t ＝4．38，P ＜0．05）；观察组治疗后血清及唾液中的 IFN-γ水平分别为（25．39±1．29）pg／mL 和（12．76±1．28）pg／mL，与治疗前相比较显著升高（t ＝10．35、8．15，均 P ＜0．01），对照组治疗后较治疗前亦显著升高（P ＜0．05）；观察组治疗后血清及唾液中的 IL-10水平分别为（27．54±1．82）pg／mL 和（9．92±0．86）pg／mL，两组均较治疗前显著降低（t ＝8．76、9．39，均 P ＜0．01，t ＝4．65、4．94，均 P ＜0．05），治疗后，观察组血清及唾液中的 IFN-γ表达水平均明显高于对照组（t ＝4．68、4．32，均 P ＜0．05），IL-10表达水平显著低于对照组（t ＝5．41、5．25，均 P ＜0．05）；治疗过程中未发现明显不良反应发生。结论养阴益气合剂联合西药治疗 OLP 具有较好的临床疗效，并能够显著升高患者血清及唾液中的 IFN-γ表达水平，降低 IL-10表达水平，对 OLP 治疗具有重要的指导价值。Objective To evaluate the clinical efficacy of Yangyin Yiqi mixture and western medicine in the treatment of oral lichen planus（OLP）and its effect on the levels of interferon -γ（IFN -γ）and interleukine -10 （IL -10）in serum and saliva.Methods Sixty patients with OLP were randomly divided into control group（n =30） and treatment group（n =30）.The control group was treated with triamcinolone acetonide and lidocaine,local injec-tion.The treatment group was treated with Yangyin Yiqi mixture on the basis of the control group.The treatment lasted two months.After treatment,the clinical efficacy,objective indicators score,levels of IFN -γand IL -10 in serum and saliva,adverse reactions were compared between the two groups.Results The overall response rate of the treatment group （86.67%）was significantly higher than that of the control group （63.33%）（χ2 =11.64,P 〈0.01）.After treatment,the two groups＇objective index score significantly reduced（t =8.52,12.51,all P 〈0.01）,and the treat-ment group＇s objective indicators rating was significantly lower than the control group （t =4.38,P 〈0.05）.After treatment,the levels of IFN -γin serum and saliva were （25.39 ±1.29）pg/mL and （12.76 ±1.28）pg/mL,which were significantly increased in the treatment group （t =10.35,8.15,all P 〈0.01）,so did the control group （P 〈0.05）.And the levels of IL -10 in serum and saliva were （27.54 ±1.82）pg/mL and （9.92 ±0.86）pg/mL,and the＆amp;nbsp;levels were significantly decreased in the two groups after treatment （t =8.76,9.39,all P 〈0.01,t =4.65,4.94,all P 〈0.05）.And levels of IFN -γin serum and saliva of the treatment group were significantly higher than those of the control group （t =4.68,4.32,all P 〈0.05）,and levels of IL -10 in serum and saliva of the treatment group were significantly lower than those of the control group （t =5.41,5.25,all P 〈0.05）.During treatment,there were no sig-nificant adverse reactions.Conclusion Yangyin Yiqi mixture c

关 键 词：口腔扁平苔藓 养阴益气合剂 干扰素 γ 白细胞介素 10 

分 类 号：R781.59[医药卫生—口腔医学]