肾结石患者丛生蛋白和相关炎症指标的表达  

Expression levels of clusterin and related in flammatory markers in patients with nephrolithiasis

作　　者：彭泳涵[1] 刘敏[1] 施晓磊[1] 陈锐[1] 李凌[1] 高小峰[1] 周铁[1] 

机构地区：[1]第二军医大学长海医院泌尿外科,上海200433

出　　处：《中国临床医学》2016年第4期470-472,共3页Chinese Journal of Clinical Medicine

基　　金：国家自然科学基金(81370806);上海市卫生局局级科研项目(2010173)~~

摘　　要：目的：探讨肾结石患者体内丛生蛋白（clusterin）的表达及炎症反应水平。方法：收集2015年7月—9月在第二军医大学长海医院泌尿外科住院的肾结石成人患者及在体检中心健康体检成人的临床资料，分别作为结石组和对照组。结石组纳入47例，中位年龄43．00（33．50～50．00）岁；对照组纳入56例，中位年龄38．50（32．50～53．00）岁。采用酶联免疫吸附试验检测两组血液和尿液中丛生蛋白水平以及血液中炎症反应指标，并进行对比分析。结果：两组间年龄和性别差异无统计学意义。结石组患者血液丛生蛋白水平低于对照组[156．85（140．07～173．62）ng／mL vs 171．48（151．51～195．09）ng／mL ，P＜0．01]，两组间尿液丛生蛋白水平差异无统计学意义[52．76（42．66～57．37）ng／m L v s 53．37（44．40～68．07）ng／m L ]。结石组患者血液白介素1β（interleukin‐1β，IL‐1β）水平高于对照组[17．92（16．26～19．18）ng／L vs 13．55（12．06～17．76）ng／L ，P＜0．01]，结石组患者血液IL‐6水平高于对照组[53．22（46．04～71．46）ng／L vs 46．58（42．34～52．63）ng／L ，P＜0．01]。结论：肾结石患者血液丛生蛋白水平降低，炎症反应水平升高。Objective：To investigate the level of clusterin expression and inflammatory response in patients with nephrolithiasis .Methods：Clinical data ,blood and urine samples of in patients with nephrolithiasis and healthy adults physical examination center were collected from July to September ,2015 in Changhai Hospital ,Second Military Medical University . Fourty‐seven cases with median age of 43 .00 （33 .50‐50 .00） years and 56 cases with median age of 38 .50 （32 .50‐53 .00） years were recruited in the stone and control group ,respectively .ELISA tests were conducted to detect serum and urine clusterin level as well as serum inflammatory markers to make comparison between two groups .Results：There were no significant differences between two groups in age and sex .Serum clusterin level was lower in the stone group than that in the control group （156 .85 [140 .07‐173 .62] ng/mL vs 171 .48 [151 .51‐195 .09] ng/mL , P〈 0 .01） ,while urine clusterin level had no significance compared with the control group （52 .76[42 .66‐57 .37] ng/mL vs 53 .37[44 .40‐68 .07]ng/mL） .Serum IL‐1βlevel was higher in the stone group than that in the control group （17 .92 [16 .26‐19 .18] ng/L vs 13 .55 [12 .06‐17 .76] ng/L ,P〈0 .01） ,and serum IL‐6 level was also higher in the stone group than that in the control group （53 .22 [46 .04‐71 .46] ng/L vs 46 .58[42 .34‐52 .63] ng/L ,P〈 0 .01） .Conclusions：Serum clusterin level decreased and the level of inflammatory response increased in patients with nephrolithiasis .

关 键 词：肾结石 炎症反应 丛生蛋白 白介素 

分 类 号：R692.4[医药卫生—泌尿科学]