聚维酮碘杀灭金黄色葡萄球菌效果与浓度的关系  

Research on efficacy-concentration relation of PVP-Ⅰ in germicidal tests against Staphylococcus aureus

作　　者：魏兰芬[1] 潘协商[1] 倪娜[2] 许激[1] 朱一凡[1] 蔡冉[1] 

机构地区：[1]浙江省疾病预防控制中心,浙江杭州310051 [2]杭州市第三人民医院

出　　处：《中国消毒学杂志》2016年第10期948-950,共3页Chinese Journal of Disinfection

摘　　要：目的研究聚维酮碘杀灭金黄色葡萄球菌的效果与浓度关系,为科学使用此类消毒剂提供参考。方法采用悬液定量杀菌试验方法,对某国外进口聚维酮碘消毒液杀灭金黄色葡萄球菌效果与浓度的关系进行观察,同时与其他指标菌作平行比较。结果该聚维酮碘消毒液在有效碘浓度4 000～500 mg/L范围内作用1.0 min,对金黄色葡萄球菌标准株和耐甲氧西林金黄色葡萄球菌（MRSA）菌株杀灭对数值范围在3.14～4.50之间;在有效碘浓度250～100 mg/L范围内作用1.0 min,对金黄色葡萄球菌标准株和MRSA菌株杀灭对数值范围在7.65～7.64之间,且对标准株与MRSA菌株杀灭对数值基本一致。对大肠杆菌、铜绿假单胞菌和白色念珠菌的杀灭效果与有效碘浓度之间未出现倒置现象。结论该聚维酮碘消毒剂对金黄色葡萄球菌杀灭效果与有效碘浓度出现倒置现象,而对其他消毒试验指标菌则未出现此现象,原因值得进一步探讨。聚维酮碘用于采血、注射、输液前皮肤消毒时,由于处理时间非常短暂存在使用风险。Objective To observe the concentration- efficacy effect of povidone iodine（ PVP- I） in germicidal tests against Staphylococcus aureus for scientific application of disinfectants. Methods Quantitative suspension germicidal test was carried out for observation on efficacy- concentration relation of an imported PVP- I solution in killing S. aureus as well as some other microorganisms for comparison. Results The killing logarithm values of the PVP- I disinfectant on standard strains and MRSA strains of S. aureus were 3. 14 ～ 4. 50 with the contact time of 1. 0 min at the concentration of4 000 ～ 500 mg / L available iodine; however,the killing logarithm values were 7. 65 ～ 7. 64 with the contact time of 1. 0 min at the concentration of 250 ～ 100 mg / L available iodine. In the above tests,standard strains and MRSA strains of S. aureus showed similar results. Meanwhile,no such reverse effect in efficacy- concentration relation was observed in the tests on Escherichia coli,Pseudomonas aeruginosa and Candida albicans. Conclusion The PVP- I disinfectant has reverse concentration- efficacy effect in germicidal tests on S. aureus but not on other tested microorganisms. More research is needed for its exact reason. It suggests the risk of PVP- I disinfectant applied in skin disinfection for a short time.

关 键 词：聚维酮碘 金黄色葡萄球菌 杀灭效果 浓度 

分 类 号：R187.2[医药卫生—流行病学]