复方瓜子金颗粒联合克拉霉素治疗上呼吸道感染的临床研究  

Clinical study on Compound Guazijin Granules combined with clarithromycin in treatment of upper respiratory tract infection

作　　者：孙建[1] 任柏沉[1] 杨帆[1] 李万成[1] 

机构地区：[1]成都医学院第一附属医院呼吸内科,四川成都610500

出　　处：《现代药物与临床》2016年第10期1559-1562,共4页Drugs & Clinic

摘　　要：目的观察复方瓜子金颗粒联合克拉霉素治疗上呼吸道感染的临床疗效。方法选取2015年1月—2015年12月成都医学院第一附属医院收治的102例急性上呼吸道感染患者,随机分为对照组和治疗组,每组各51例。对照组口服克拉霉素片,0.5 g/次,1次/d。治疗组在对照组的基础上口服复方瓜子金颗粒,1袋/次,3次/d。两组均连续治疗7 d。观察两组的临床疗效、临床症状体征改善情况,同时比较两组患者血浆白细胞介素-6(IL-6)和超敏C反应蛋白(hs-CRP)水平。结果治疗后,对照组和治疗组的总有效率分别为78.43%、92.16%,两组总有效率比较差异具有统计学意义(P<0.05)。治疗后,治疗组退热时间、咽痛消失时间、止咳时间、鼻塞流涕消失时间都显著短于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者IL-6和hs-CRP水平显著降低,同组治疗前后差异有统计学意义(P<0.05);且治疗组上述指标的降低程度优于对照组,两组比较差异具有统计学意义(P<0.05)。结论复方瓜子金颗粒联合克拉霉素治疗上呼吸道感染疗效确切,临床症状体征和炎性指标改善明显,不良反应较轻,具有一定的临床推广应用价值。Objective To observe the clinical curative effect of Compound Guazijin Granules combined with clarithromycin in treatment of upper respiratory tract infection. Methods Patients（102 cases） with upper respiratory tract infection in the First Affiliated Hospital of Chengdu Medical College from January 2015 to December 2015 were divided into control and treatment groups, and each group had 51 cases. The patients in the control group were po administered with Clarithromycin Tablets, 0.5 g/time, once daily. The patients in the treatment group were po administered with Compound Guazijin Granules on the basis of the control group, one bag/time, three times daily. The patients in two groups were treated for 7 d. After treatment, the improvement of the clinical efficacies and clinical symptoms and signs were evaluated, and the levels of IL-6 and hs-CRP in two groups before and after treatment were compared. Results After treatment, the efficacies in the control and treatment groups were 78.43% and 92.16%, respectively, and there were differences between two groups（P〈0.05）. After treatment, disappear time of fever, pharyngalgia, cough, and stuffy running nose in the treatment group were significantly shorter than those in the control group, with significant difference between two groups（P〈0.05）. After treatment, IL-6 and hs-CRP in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. And the decrease degree of the observational indexes in the treatment group was significantly lower than those in the control group, with significant difference between two groups（P〈0.05）. Conclusion Compound Guazijin Granules combined with clarithromycin has an obvious curative effect in treatment of upper respiratory tract infection, can significantly improve the clinical symptoms and signs and inflammatory indexes with slight side effects, which has a certain clinical application value.

关 键 词：复方瓜子金颗粒 克拉霉素片 上呼吸道感染 白细胞介素 超敏C反应蛋白 

分 类 号：R974[医药卫生—药品]